Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19

被引：26

作者：

Buxeda, Anna ^{[1
]}

Arias-Cabrales, Carlos ^{[1
]}

Perez-Saez, Maria Jose ^{[1
]}

Cacho, Judit ^{[2
]}

Pelegrin, Sheila Cabello ^{[3
]}

Melilli, Edoardo ^{[4
]}

Aladren, Maria Jose ^{[5
]}

Galeano, Cristina ^{[6
]}

Lorenzo, Inmaculada ^{[7
]}

Mazuecos, Auxiliadora ^{[8
]}

Saura, Isabel Maria ^{[9
]}

Franco, Antonio ^{[10
]}

Ruiz-Fuentes, Maria del Carmen ^{[11
]}

Sanchez-Camara, Luis Alberto ^{[12
]}

Siverio, Orlando ^{[13
]}

Martin, Maria Luisa ^{[14
]}

Gonzalez-Garcia, Elena ^{[15
]}

Lopez, Veronica ^{[16
,17
]}

Martin-Moreno, Paloma Leticia ^{[18
]}

Moina, Inigo ^{[19
]}

Berrio, Esperanza Moral ^{[20
]}

Moreso, Francesc ^{[21
]}

Portoles, Jose Maria ^{[22
]}

Santana-Estupinan, Raquel ^{[23
]}

Zarraga, Sofia ^{[24
]}

Canal, Cristina ^{[25
]}

Sanchez-Alvarez, Emilio ^{[26
]}

Pascual, Julio ^{[1
]}

Crespo, Marta ^{[1
]}

机构：

[1] Hosp Mar, Inst Mar Med Res IMIM, Dept Nephrol, Red Invest Renal RED inREN RD16 0009 0013, Barcelona, Spain

[2] Hosp Badalona Germans Trias & Pujol, Dept Nephrol, Barcelona, Spain

[3] Hosp Univ Son Espases, Dept Nephrol, Palma De Mallorca, Spain

[4] Hosp Univ Bellvitge, Dept Nephrol, Barcelona, Spain

[5] Hosp Univ Miguel Servet, Dept Nephrol, Zaragoza, Spain

[6] Hosp Univ Ramon y Cajal, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Dept Nephrol, Madrid, Spain

[7] Hosp Gen Albacete, Dept Nephrol, Albacete, Spain

[8] Hosp Univ Puerta del Mar, Dept Nephrol, Cadiz, Spain

[9] Hosp Univ Virgen de la Arrixaca, Dept Nephrol, Murcia, Spain

[10] Hosp Gen Univ Alicante, Dept Nephrol, Alicante, Spain

[11] Hosp Univ Virgen de las Nieves, Dept Nephrol, Granada, Spain

[12] Hosp Gen Univ Gregorio Maranon, Inst Invest Sanitaria Gregorio Maranon IiSGM, Dept Nephrol, Madrid, Spain

[13] Hosp Univ Nuestra Senora de la Candelaria, Dept Nephrol, Tenerife, Spain

[14] Hosp Arnau Vilanova, Dept Nephrol, Lleida, Spain

[15] Hosp Univ La Paz, Dept Nephrol, Madrid, Spain

[16] Hosp Reg Univ Malaga, Dept Nephrol, Malaga, Spain

[17] Univ Malaga, Inst Invest Biomed Malaga IBIMA, Red Invest Renal REDinREN RD16 0009 0006, Malaga, Spain

[18] Clin Univ Navarra, Navarra Inst Hlth Res IdiSNA, Dept Nephrol, Pamplona, Spain

[19] Hosp Univ Basurto, Dept Nephrol, Bilbao, Spain

[20] Hosp Gen Univ Ciudad Real, Dept Nephrol, Ciudad Real, Spain

[21] Hosp Univ Vall dHebron, Dept Nephrol, Barcelona, Spain

[22] Hosp Univ Puerta de Hierro, Dept Nephrol, Madrid, Spain

[23] Hosp Univ Gran Canaria Doctor Negrin, Dept Nephrol, Las Palmas Gran Canaria, Spain

[24] Hosp Univ Cruces, Dept Nephrol, Bilbao, Spain

[25] Fundacio Puigvert, Dept Nephrol, Barcelona, Spain

[26] Hosp Cabuenes, Dept Nephrol, Gijon, Spain

来源：

KIDNEY INTERNATIONAL REPORTS | 2021年 / 6卷 / 09期

关键词：

acute kidney injury; immunosuppression; kidney transplantation; remdesivir; SARS-CoV2l; MORTALITY; INJURY;

D O I：

10.1016/j.ekir.2021.06.023

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Remdesivir has demonstrated antiviral activity against coronavirus, shortening the time to recovery in adults hospitalized with moderate/severe COVID-19. Severe adverse events such as acute kidney injury have been reported. Scant data are available on the use and safety of remdesivir in kidney transplant recipients. Methods: We present a multicenter cohort study of 51 kidney transplant recipients with COVID-19 treated with remdesivir. Outcomes and safety were assessed. Results: Mean age at diagnosis was 60 years, with a median time since kidney transplant of 4.5 years. Mean time since admission to remdesivir was 2 days. Twenty-eight patients (54.9%) required mechanical ventilation (19 noninvasive). Mortality was 18.9% and markedly higher if aged >= 65 years (45% vs. 3.2% in younger patients). Acute kidney injury was present in 27.7% of patients, but was diagnosed in 50% before treatment. No patients required remdesivir discontinuation because of adverse events. We did not find significant hepatoxicity or systemic symptoms resulting from the drug. Conclusion: In our cohort of kidney transplant recipients, remdesivir was well tolerated and safe in renal and hepatic toxicity, but randomized trials are needed to assess its efficacy.

引用

页码：2305 / 2315

页数：11

共 41 条

[1] Remdesivir in Patients with Acute or Chronic Kidney Disease and COVID-19 [J].

Adamsick, Meagan L. ;

Gandhi, Ronak G. ;

Bidell, Monique R. ;

Elshaboury, Ramy H. ;

Bhattacharyya, Roby P. ;

Kim, Arthur Y. ;

Nigwekar, Sagar ;

Rhee, Eugene P. ;

Sise, Meghan E. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020, 31 (07) :1384-1386

[2] Use of Remdesivir in Patients With COVID-19 on Hemodialysis: A Study of Safety and Tolerance [J].

Aiswarya, Dhanapalan ;

Arumugam, Venkatesh ;

Dineshkumar, Thanigachalam ;

Gopalakrishnan, Natarajan ;

Lamech, Tanuj Moses ;

Nithya, Govindasamy ;

Sastry, Bhagavatula V. R. H. ;

Vathsalyan, Paulpandian ;

Dhanapriya, Jeyachandran ;

Sakthirajan, Ramanathan .

KIDNEY INTERNATIONAL REPORTS, 2021, 6 (03) :586-593

[3] Covid-19 and Kidney Transplantation [J].

Akalin, Enver ;

Azzi, Yorg ;

Bartash, Rachel ;

Seethamraju, Harish ;

Parides, Michael ;

Hemmige, Vagish ;

Ross, Michael ;

Forest, Stefanie ;

Goldstein, Yitz D. ;

Ajaimy, Maria ;

Liriano-Ward, Luz ;

Pynadath, Cindy ;

Loarte-Campos, Pablo ;

Nandigam, Purna B. ;

Graham, Jay ;

Le, Marie ;

Rocca, Juan ;

Kinkhabwala, Milan .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (25) :2475-2477

[4]

[Anonymous], 30 RENAVE CNE CNMISC

[5]

[Anonymous], 66 RENAVE CNE CNMISC

[6] Compassionate remdesivir treatment of severe Covid-19 pneumonia in intensive care unit (ICU) and Non-ICU patients: Clinical outcome and differences in post-treatment hospitalisation status [J].

Antinori, Spinello ;

Cossu, Maria Vittoria ;

Ridolfo, Anna Lisa ;

Rech, Roberto ;

Bonazzetti, Cecilia ;

Pagani, Gabriele ;

Gubertini, Guido ;

Coen, Massimo ;

Magni, Carlo ;

Castelli, Antonio ;

Borghi, Beatrice ;

Colombo, Riccardo ;

Giorgi, Riccardo ;

Angeli, Elena ;

Mileto, Davide ;

Milazzo, Laura ;

Vimercati, Stefania ;

Pellicciotta, Martina ;

Corbellino, Mario ;

Torre, Alessandro ;

Rusconi, Stefano ;

Oreni, Letizia ;

Gismondo, Maria Rita ;

Giacomelli, Andrea ;

Meroni, Luca ;

Rizzardini, Giuliano ;

Galli, Massimo .

PHARMACOLOGICAL RESEARCH, 2020, 158

[7] Mortality Benefit of Remdesivir in COVID-19: A Systematic Review and Meta-Analysis [J].

Bansal, Vikas ;

Mahapure, Kiran S. ;

Bhurwal, Abhishek ;

Gupta, Ishita ;

Hassanain, Sahar ;

Makadia, Janaki ;

Madas, Nimisha ;

Armaly, Paige ;

Singh, Romil ;

Mehra, Ishita ;

O'Horo, John C. ;

Kashyap, Rahul .

FRONTIERS IN MEDICINE, 2021, 7

[8] Remdesivir for the Treatment of Covid-19-Final Report [J].

Beigel, John H. ;

Tomashek, Kay M. ;

Dodd, Lori E. ;

Mehta, Aneesh K. ;

Zingman, Barry S. ;

Kalil, Andre C. ;

Hohmann, Elizabeth ;

Chu, Helen Y. ;

Luetkemeyer, Annie ;

Kline, Susan ;

de Castilla, Diego Lopez ;

Finberg, Robert W. ;

Dierberg, Kerry ;

Tapson, Victor ;

Hsieh, Lanny ;

Patterson, Thomas F. ;

Paredes, Roger ;

Sweeney, Daniel A. ;

Short, William R. ;

Touloumi, Giota ;

Lye, David Chien ;

Ohmagari, Norio ;

Oh, Myoung-don ;

Ruiz-Palacios, Guillermo M. ;

Benfield, Thomas ;

Faetkenheuer, Gerd ;

Kortepeter, Mark G. ;

Atmar, Robert L. ;

Creech, C. Buddy ;

Lundgren, Jens ;

Babiker, Abdel G. ;

Pett, Sarah ;

Neaton, James D. ;

Burgess, Timothy H. ;

Bonnett, Tyler ;

Green, Michelle ;

Makowski, Mat ;

Osinusi, Anu ;

Nayak, Seema ;

Lane, H. Clifford .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (19) :1813-1826

[9]

Cao B, 2020, NEW ENGL J MED, V382, P1787, DOI [10.1056/NEJMoa2001282, 10.1056/NEJMc2008043]

[10] COVID-19 and kidney transplantation: Results from the TANGO International Transplant Consortium [J].

Cravedi, Paolo ;

Mothi, Suraj S. ;

Azzi, Yorg ;

Haverly, Meredith ;

Farouk, Samira S. ;

Perez-Saez, Maria J. ;

Redondo-Pachon, Maria D. ;

Murphy, Barbara ;

Florman, Sander ;

Cyrino, Laura G. ;

Grafals, Monica ;

Venkataraman, Sandheep ;

Cheng, Xingxing S. ;

Wang, Aileen X. ;

Zaza, Gianluigi ;

Ranghino, Andrea ;

Furian, Lucrezia ;

Manrique, Joaquin ;

Maggiore, Umberto ;

Gandolfini, Ilaria ;

Agrawal, Nikhil ;

Patel, Het ;

Akalin, Enver ;

Riella, Leonardo, V .

AMERICAN JOURNAL OF TRANSPLANTATION, 2020, 20 (11) :3140-3148

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