Amphiphilic PEG-Based Ether-Anhydride Terpolymers: Synthesis, Characterization, and Micellization

被引：13
作者：
Zhao, Aijun [1 ]
Zhou, Qi [1 ]
Chen, Tao [1 ]
Weng, Jie [1 ]
Zhou, Shaobing [1 ]
机构：
[1] SW Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Minist Educ, Chengdu 610031, Peoples R China
来源：
JOURNAL OF APPLIED POLYMER SCIENCE | 2010年 / 118卷 / 06期
基金：
中国国家自然科学基金;
关键词：
biodegradable; amphiphilic; micelles; polymer; nanoparticles; BLOCK-COPOLYMER MICELLES; DRUG-DELIVERY; POLYMERIC MICELLES; POLYANHYDRIDES; GELATION; RELEASE; DESIGN;
D O I：
10.1002/app.32724
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A series of amphiphilic poly(ether-anhydrides) terpolymers composed of sebacic acid, 1,3-bis(carboxyphenoxy) propane, and poly(ethylene glycol) (PEG) were synthesized via melt-condensation polymerization. The resultant terpolymers were characterized by H-1-nuclear magnetic resonance spectroscopy (H-1-NMR), Fourier transform infrared spectroscopy, gel permeation chromatography, X-ray diffraction, polarization optical microscope, differential scanning calorimeter, and water contact angle. Biodegradable micelles were prepared via a precipitation method through self-emulsification. The shape of these micelles was uniform and spheric according to the atomic force microscopy and transmission electron microscopy images. The dynamic light scattering measurements indicated that the diameters of micelles were typically in the range of 118-359 nm. The results displayed the PEG-based ether-anhydride terpolymers may be of great potential as nanoscaled carriers for drug delivery system. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 118: 3576-3585, 2010
引用
收藏
页码：3576 / 3585
页数：10
相关论文
共 39 条
  • [1] Amphiphilic block copolymers for drug delivery
    Adams, ML
    Lavasanifar, A
    Kwon, GS
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 2003, 92 (07) : 1343 - 1355
  • [2] BOMB AJ, 1987, J POLYM SCI A, V25, P3373
  • [3] CHENG KC, 2003, BIOMATERIALS, V24, P47
  • [4] EDITH M, 1993, MACROMOLECULES, V26, P6749
  • [5] Poly(ether-anhydride) dry powder aerosols for sustained drug delivery in the lungs
    Fiegel, J
    Fu, H
    Hanes, J
    [J]. JOURNAL OF CONTROLLED RELEASE, 2004, 96 (03) : 411 - 423
  • [6] In vitro release of the mTOR inhibitor rapamycin from poly(ethylene glycol)-b-poly(ε-caprolactone) micelles
    Forrest, ML
    Won, CY
    Malick, AW
    Kwon, GS
    [J]. JOURNAL OF CONTROLLED RELEASE, 2006, 110 (02) : 370 - 377
  • [7] FRIEDERIKE V, 2002, BIOMATERIALS, V23, P221
  • [8] Synthesis and characterization of PEG-based ether-anhydride terpolymers: Novel polymers for controlled drug delivery
    Fu, J
    Fiegel, J
    Hanes, J
    [J]. MACROMOLECULES, 2004, 37 (19) : 7174 - 7180
  • [9] Controlled and targeted tumor chemotherapy by micellar-encapsulated drug and ultrasound
    Gao, ZG
    Fain, HD
    Rapoport, N
    [J]. JOURNAL OF CONTROLLED RELEASE, 2005, 102 (01) : 203 - 222
  • [10] Block copolymer micelles: preparation, characterization and application in drug delivery
    Gaucher, G
    Dufresne, MH
    Sant, VP
    Kang, N
    Maysinger, D
    Leroux, JC
    [J]. JOURNAL OF CONTROLLED RELEASE, 2005, 109 (1-3) : 169 - 188
1234