Absence of Association between Polymorphisms in the RING E3 Ubiquitin Protein Ligase Gene and Ex Vivo Susceptibility to Conventional Antimalarial Drugs in Plasmodium falciparum Isolates from Dakar, Senegal

被引:5
作者
Gendrot, Mathieu [1 ,2 ]
Fall, Becaye [3 ]
Madamet, Marylin [2 ,4 ,5 ]
Fall, Mansour [6 ]
Wade, Khalifa Ababacar [7 ]
Amalvict, Remy [2 ,4 ,5 ]
Nakoulima, Aminata [8 ]
Benoit, Nicolas [2 ,4 ,5 ]
Diawara, Silman [3 ]
Dieme, Yaya [3 ]
Diatta, Bakary [7 ,9 ]
Wade, Boubacar [9 ]
Pradines, Bruno [1 ,2 ,3 ,5 ]
机构
[1] Inst Rech Biomed Armees, Dept Malad Infect, Unite Parasitol & Entomol, Bretigny Sur Orge, France
[2] Aix Marseille Univ, CNRS 7278, Inserm 1095, IRD 198,UM 63,Unite Rech Malad Infect & Trop Emer, Marseille, France
[3] Hop Principal Dakar, Federat Labs, Lab Etud Chimiosensibil Paludisme, Dakar, Senegal
[4] Hop Instruct Armees, Inst Rech Biomed Armees, Equipe Residente Rech Infectiol Trop, Marseille, France
[5] Ctr Natl Reference Paludisme, Marseille, France
[6] Hop Principal Dakar, Serv Reanimat Med, Dakar, Senegal
[7] Hop Principal Dakar, Serv Urgences, Dakar, Senegal
[8] Hop Principal Dakar, Serv Pediat, Dakar, Senegal
[9] Hop Principal Dakar, Chefferie, Dakar, Senegal
关键词
ARTEMISININ RESISTANCE; MALARIA PARASITE; IN-VITRO; PIPERAQUINE; CAMBODIA; STANDARD; BIOLOGY; SYSTEM;
D O I
10.1128/AAC.03105-15
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The RING E3 ubiquitin protein ligase is crucial for facilitating the transfer of ubiquitin. The only polymorphism identified in the E3 ubiquitin protein ligase gene was the D113N mutation (62.5%) but was not significantly associated with the 50% inhibitory concentration (IC50) of conventional antimalarial drugs. However, some mutated isolates (D113N) present a trend of reduced susceptibility to piperaquine (P = 0.0938). To evaluate the association of D113N polymorphism with susceptibility to antimalarials, more isolates are necessary.
引用
收藏
页码:5010 / 5013
页数:4
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