Absence of Association between Polymorphisms in the RING E3 Ubiquitin Protein Ligase Gene and Ex Vivo Susceptibility to Conventional Antimalarial Drugs in Plasmodium falciparum Isolates from Dakar, Senegal

被引：5

作者：

Gendrot, Mathieu ^{[1
,2
]}

Fall, Becaye ^{[3
]}

Madamet, Marylin ^{[2
,4
,5
]}

Fall, Mansour ^{[6
]}

Wade, Khalifa Ababacar ^{[7
]}

Amalvict, Remy ^{[2
,4
,5
]}

Nakoulima, Aminata ^{[8
]}

Benoit, Nicolas ^{[2
,4
,5
]}

Diawara, Silman ^{[3
]}

Dieme, Yaya ^{[3
]}

Diatta, Bakary ^{[7
,9
]}

Wade, Boubacar ^{[9
]}

Pradines, Bruno ^{[1
,2
,3
,5
]}

机构：

[1] Inst Rech Biomed Armees, Dept Malad Infect, Unite Parasitol & Entomol, Bretigny Sur Orge, France

[2] Aix Marseille Univ, CNRS 7278, Inserm 1095, IRD 198,UM 63,Unite Rech Malad Infect & Trop Emer, Marseille, France

[3] Hop Principal Dakar, Federat Labs, Lab Etud Chimiosensibil Paludisme, Dakar, Senegal

[4] Hop Instruct Armees, Inst Rech Biomed Armees, Equipe Residente Rech Infectiol Trop, Marseille, France

[5] Ctr Natl Reference Paludisme, Marseille, France

[6] Hop Principal Dakar, Serv Reanimat Med, Dakar, Senegal

[7] Hop Principal Dakar, Serv Urgences, Dakar, Senegal

[8] Hop Principal Dakar, Serv Pediat, Dakar, Senegal

[9] Hop Principal Dakar, Chefferie, Dakar, Senegal

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 08期

关键词：

ARTEMISININ RESISTANCE; MALARIA PARASITE; IN-VITRO; PIPERAQUINE; CAMBODIA; STANDARD; BIOLOGY; SYSTEM;

D O I：

10.1128/AAC.03105-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The RING E3 ubiquitin protein ligase is crucial for facilitating the transfer of ubiquitin. The only polymorphism identified in the E3 ubiquitin protein ligase gene was the D113N mutation (62.5%) but was not significantly associated with the 50% inhibitory concentration (IC50) of conventional antimalarial drugs. However, some mutated isolates (D113N) present a trend of reduced susceptibility to piperaquine (P = 0.0938). To evaluate the association of D113N polymorphism with susceptibility to antimalarials, more isolates are necessary.

引用

页码：5010 / 5013

页数：4

共 14 条

[1] Spread of Artemisinin Resistance in Plasmodium falciparum Malaria [J].

Ashley, E. A. ;

Dhorda, M. ;

Fairhurst, R. M. ;

Amaratunga, C. ;

Lim, P. ;

Suon, S. ;

Sreng, S. ;

Anderson, J. M. ;

Mao, S. ;

Sam, B. ;

Sopha, C. ;

Chuor, C. M. ;

Nguon, C. ;

Sovannaroth, S. ;

Pukrittayakamee, S. ;

Jittamala, P. ;

Chotivanich, K. ;

Chutasmit, K. ;

Suchatsoonthorn, C. ;

Runcharoen, R. ;

Hien, T. T. ;

Thuy-Nhien, N. T. ;

Thanh, N. V. ;

Phu, N. H. ;

Htut, Y. ;

Han, K-T. ;

Aye, K. H. ;

Mokuolu, O. A. ;

Olaosebikan, R. R. ;

Folaranmi, O. O. ;

Mayxay, M. ;

Khanthavong, M. ;

Hongvanthong, B. ;

Newton, P. N. ;

Onyamboko, M. A. ;

Fanello, C. I. ;

Tshefu, A. K. ;

Mishra, N. ;

Valecha, N. ;

Phyo, A. P. ;

Nosten, F. ;

Yi, P. ;

Tripura, R. ;

Borrmann, S. ;

Bashraheil, M. ;

Peshu, J. ;

Faiz, M. A. ;

Ghose, A. ;

Hossain, M. A. ;

Samad, R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (05) :411-423

[2] Artemisinin Resistance in Plasmodium falciparum Malaria. [J].

Dondorp, Arjen M. ;

Nosten, Francois ;

Yi, Poravuth ;

Das, Debashish ;

Phyo, Aung Phae ;

Tarning, Joel ;

Lwin, Khin Maung ;

Ariey, Frederic ;

Hanpithakpong, Warunee ;

Lee, Sue J. ;

Ringwald, Pascal ;

Silamut, Kamolrat ;

Imwong, Mallika ;

Chotivanich, Kesinee ;

Lim, Pharath ;

Herdman, Trent ;

An, Sen Sam ;

Yeung, Shunmay ;

Singhasivanon, Pratap ;

Day, Nicholas P. J. ;

Lindegardh, Niklas ;

Socheat, Duong ;

White, Nicholas J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (05) :455-467

[3] Plasmodium falciparum susceptibility to standard and potential anti-malarial drugs in Dakar, Senegal, during the 2013-2014 malaria season [J].

Fall, Becaye ;

Camara, Cheikhou ;

Fall, Mansour ;

Nakoulima, Aminata ;

Dionne, Pierre ;

Diatta, Bakary ;

Dieme, Yaya ;

Wade, Boubacar ;

Pradines, Bruno .

MALARIA JOURNAL, 2015, 14

[4] Ex vivo susceptibility of Plasmodium falciparum isolates from Dakar, Senegal, to seven standard anti-malarial drugs [J].

Fall, Becaye ;

Diawara, Silmane ;

Sow, Kowry ;

Baret, Eric ;

Diatta, Bakary ;

Fall, Khadidiatou B. ;

Mbaye, Pape S. ;

Fall, Fatou ;

Dieme, Yaya ;

Rogier, Christophe ;

Wade, Boubacar ;

Bercion, Raymond ;

Pradines, Bruno .

MALARIA JOURNAL, 2011, 10

[5] The ubiquitin system: an essential component to unlocking the secrets of malaria parasite biology [J].

Hamilton, Michael J. ;

Lee, Michael ;

Le Roch, Karine G. .

MOLECULAR BIOSYSTEMS, 2014, 10 (04) :715-723

[6] The ubiquitin system [J].

Hershko, A ;

Ciechanover, A .

ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 :425-479

[7] Evidence of Plasmodium falciparum Malaria Multidrug Resistance to Artemisinin and Piperaquine in Western Cambodia: Dihydroartemisinin-Piperaquine Open-Label Multicenter Clinical Assessment [J].

Leang, Rithea ;

Taylor, Walter R. J. ;

Bouth, Denis Mey ;

Song, Lijiang ;

Tarning, Joel ;

Char, Meng Chuor ;

Kim, Saorin ;

Witkowski, Benoit ;

Duru, Valentine ;

Domergue, Anais ;

Khim, Nimol ;

Ringwald, Pascal ;

Menard, Didier .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (08) :4719-4726

[8] Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite [J].

Park, Daniel J. ;

Lukens, Amanda K. ;

Neafsey, Daniel E. ;

Schaffner, Stephen F. ;

Chang, Hsiao-Han ;

Valim, Clarissa ;

Ribacke, Ulf ;

Van Tyne, Daria ;

Galinsky, Kevin ;

Galligan, Meghan ;

Becker, Justin S. ;

Ndiaye, Daouda ;

Mboup, Souleymane ;

Wiegand, Roger C. ;

Hartl, Daniel L. ;

Sabeti, Pardis C. ;

Wirth, Dyann F. ;

Volkman, Sarah K. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (32) :13052-13057

[9] Multinormal in vitro distribution of Plasmodium falciparum susceptibility to piperaquine and pyronaridine [J].

Pascual, Aurelie ;

Madamet, Marilyn ;

Briolant, Sebastien ;

Gaillard, Tiphaine ;

Amalvict, Remy ;

Benoit, Nicolas ;

Travers, Dominique ;

Pradines, Bruno .

MALARIA JOURNAL, 2015, 14

[10]

Ribacke U., 2012, P 61 M AM SOC TROP M, P299

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