Recurrent episodes of deep vein thrombosis in a young man

被引：0
作者：
Giotopoulou, S
Giafis, K
Dokou, E
Tsaousi, C
Kolaitis, N
Vartholomatos, G
机构：
[1] Univ Hosp Ioannina, Hematol Lab, Unit Mocolecular Biol, Ioannina, Greece
[2] Reg Hosp Cefalonia, Cefalonia, Greece
来源：
INTERNATIONAL ANGIOLOGY | 2003年 / 22卷 / 02期
关键词：
venous thrombosis; diagnosis; genetics; therapy;
D O I：
暂无
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
We present the case of a 32-year-old man suffering from recurrent episodes of deep vein thrombosis (DVT). He was heterozygous for the G1691A mutation in the Factor V gene. His father was heterozygous for the same mutation and had a unique episode of DVT after a fracture of the tibia. Genetic predisposition significantly influences the prevalence of thrombotic events, however, additional unknown factors may be involved in the initiation and recurrence of venous thromboembolism.
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页码：199 / 201
页数：3
相关论文
共 16 条
  • [1] Three months versus one year of oral anticoagulant therapy for idiopathic deep venous thrombosis.
    Agnelli, G
    Prandoni, P
    Santamaria, MG
    Bagatella, P
    Iorio, A
    Bazzan, M
    Moia, M
    Guazzaloca, G
    Bertoldi, A
    Tomasi, C
    Scannapieco, G
    Ageno, W
    Ascani, A
    Villalta, S
    Frulla, M
    Mosena, L
    Girolami, A
    Vaccarino, A
    Alatri, A
    Palareti, G
    Marchesi, M
    Ambrosio, GB
    Parisi, R
    Doria, S
    Steidl, L
    Ambrosini, F
    Silingardi, M
    Ghirarduzzi, A
    Iori, I
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (03) : 165 - 169
  • [2] Prevalence of genetic mutations that predispose to thrombophilia in a Greek Cypriot population
    Angelopoulou, K
    Nicolaides, A
    Deltas, CC
    [J]. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2000, 6 (02) : 104 - 107
  • [3] The role of prothrombotic mutations in patients with Buerger's disease
    Avcu, F
    Akar, E
    Demirkiliç, U
    Yilmaz, E
    Akar, N
    Yalçin, A
    [J]. THROMBOSIS RESEARCH, 2000, 100 (03) : 143 - 147
  • [4] MUTATION IN BLOOD-COAGULATION FACTOR-V ASSOCIATED WITH RESISTANCE TO ACTIVATED PROTEIN-C
    BERTINA, RM
    KOELEMAN, BPC
    KOSTER, T
    ROSENDAAL, FR
    DIRVEN, RJ
    DERONDE, H
    VANDERVELDEN, PA
    REITSMA, PH
    [J]. NATURE, 1994, 369 (6475) : 64 - 67
  • [5] Lipoprotein (a) binds and inactivates tissue factor pathway inhibitor: a novel link between lipoproteins and thrombosis
    Caplice, NM
    Panetta, C
    Peterson, TE
    Kleppe, LS
    Mueske, CS
    Kostner, GM
    Broze, GJ
    Simari, RD
    [J]. BLOOD, 2001, 98 (10) : 2980 - 2987
  • [6] FRADE LJG, 1987, THROMB RES, V47, P533
  • [7] Ioannou HV, 2000, INT ANGIOL, V19, P314
  • [8] Lane DA, 1996, THROMB HAEMOSTASIS, V76, P651
  • [9] A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis
    Poort, SR
    Rosendaal, FR
    Reitsma, PH
    Bertina, RM
    [J]. BLOOD, 1996, 88 (10) : 3698 - 3703
  • [10] Reitsma PH, 2000, HAEMOSTASIS, V30, P1
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