Bipotential B-macrophage progenitors are present in adult bone marrow

被引：155

作者：

Montecino-Rodriguez, E

Leathers, H

Dorshkind, K ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Sch Med, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA

来源：

NATURE IMMUNOLOGY | 2001年 / 2卷 / 01期

关键词：

D O I：

10.1038/83210

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

According to the current model of adult hematopoiesis, differentiation of pluripotential hematopoietic stem cells into common myeloid- and lymphoid-committed progenitors establishes an early separation between the myeloid and lymphoid lineages. This report describes a rare and previously unidentified CD45R-CD19(+) B cell progenitor population in postnatal bone marrow that can also generate macrophages. In addition to the definition of this B-lineage intermediate, the data indicate that a developmental relationship between the B and macrophage lineages is retained during postnatal hematopoiesis.

引用

页码：83 / 88

页数：6

共 50 条

[11]

DORSHKIND K, 1986, J IMMUNOL, V136, P422

[12]

DZIERZAK E, 1990, MOL BIOL B CELL T CE, P3

[13]

GREAVES MF, 1986, BLOOD, V67, P1

[14] CHARACTERIZATION OF A 70Z/3 PRE-B-CELL DERIVED MACROPHAGE CLONE - DIFFERENTIAL EXPRESSION OF HOX FAMILY GENES [J].