The Role of Immunotherapy to Overcome Resistance in Viral-Associated Head and Neck Cancer

被引：7

作者：

Pharaon, Rebecca R. ^{[1
]}

Xing, Yan ^{[1
]}

Agulnik, Mark ^{[1
]}

Villaflor, Victoria M. ^{[1
]}

机构：

[1] City Hope Natl Med Ctr, Dept Med Oncol & Therapeut Res, Duarte, CA 91010 USA

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 11卷

关键词：

immunotherapy; head and neck cancer; oropharyngeal squamous cell carcinoma; nasopharyngeal carcinoma; viral-associated cancers; human papillomavirus; Epstein-Barr virus; SQUAMOUS-CELL CARCINOMA; EPSTEIN-BARR-VIRUS; PHASE-II TRIAL; HUMAN-PAPILLOMAVIRUS; NASOPHARYNGEAL CARCINOMA; OPEN-LABEL; OROPHARYNGEAL CANCER; ANTITUMOR-ACTIVITY; METASTATIC HEAD; PLUS CETUXIMAB;

D O I：

10.3389/fonc.2021.649963

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A subset of head and neck cancers arising in the oropharynx and the nasopharynx are associated with human papillomavirus or Epstein-Barr virus. Unfortunately, limited treatment options exist once patients develop recurrent or metastatic disease in these cancers. Interest has risen in utilizing novel strategies including combination immune checkpoint inhibitors, vaccines, and adoptive cellular therapy, to improve treatment response and outcomes. Several ongoing studies are investigating the potential to overcome resistance to standard of care chemoradiation therapy with monotherapy or combination immunotherapy strategies in these viral-associated head and neck cancers.

引用

页数：12

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