NPR-C gene polymorphism is associated with increased susceptibility to coronary artery disease in Chinese Han population: a multicenter study

被引：15

作者：

Hu, Qin ^{[1
,2
]}

Liu, Qiji ^{[3
]}

Wang, Shasha ^{[1
,2
]}

Zhen, Xi ^{[1
,2
]}

Zhang, Zhimian ^{[4
]}

Lv, Ruijuan ^{[5
]}

Jiang, Guihua ^{[1
,2
]}

Ma, Zhiyong ^{[1
,2
]}

He, Hong ^{[1
,2
]}

Li, Daqing ^{[1
,2
]}

Liu, Xiaoling ^{[1
,2
]}

Gao, Fei ^{[1
,2
]}

Li, Jifu ^{[1
,2
]}

Li, Li ^{[1
,2
]}

Zhang, Mei ^{[1
,2
]}

Ji, Xiaoping ^{[1
,2
]}

Chen, Yuguo ^{[5
]}

Wang, Daowen ^{[6
]}

Huang, Dejia ^{[7
]}

Ma, Aiqun ^{[8
]}

Huang, Wei ^{[9
]}

Zhao, Yuxia ^{[1
,2
]}

Gong, Yaoqin ^{[3
]}

Zhang, Cheng ^{[1
,2
]}

Zhang, Yun ^{[1
,2
]}

机构：

[1] Shandong Univ, Qilu Hosp, Chinese Minist Educ, Key Lab Cardiovasc Remodeling & Funct Res, Jinan 250100, Shandong, Peoples R China

[2] Shandong Univ, Qilu Hosp, Dept Cardiol, Chinese Minist Hlth, Jinan 250100, Shandong, Peoples R China

[3] Shandong Univ, Dept Med Genet, Sch Med, Key Lab Expt Teratol,Minist Educ, Jinan 250100, Shandong, Peoples R China

[4] Shandong Univ, Qilu Hosp, Med Examinat Ctr, Jinan 250100, Shandong, Peoples R China

[5] Shandong Univ, Qilu Hosp, Dept Emergency, Jinan 250100, Shandong, Peoples R China

[6] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Internal Med, Wuhan 430074, Peoples R China

[7] Sichuan Univ, West China Hosp, Div Cardiol, Dept Med, Chengdu 610064, Sichuan, Peoples R China

[8] Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Dept Cardiol & Periphery Vasc Med, Xian, Shaanxi, Peoples R China

[9] Shanghai Jiao Tong Univ, Dept Genet, Chinese Natl Human Genome Ctr, Ruijin Hosp,Sch Med, Shanghai, Peoples R China

来源：

ONCOTARGET | 2016年 / 7卷 / 23期

基金：

中国国家自然科学基金;

关键词：

natriuretic peptide receptor C; coronary artery disease; genome-wide association studies; single nucleotide polymorphisms; susceptibility gene; Pathology Section; GENOME-WIDE ASSOCIATION; NATRIURETIC PEPTIDE; RECEPTORS; VARIANTS; HEART; LOCI;

D O I：

10.18632/oncotarget.9358

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To find a new locus that confers significant susceptibility to CAD in Chinese Han population, a genome-wide association study in 200 "extreme individuals" from a Shandong cohort and a pathway-based candidate gene study from a Shanghai cohort (293 CAD/293 controls) were simultaneously performed. Amongst them, 13 SNPs associated with CAD were selected to conduct validation and replication studies in additional 3363 CAD patients and 3148 controls. A novel locus rs700926 in natriuretic peptide receptor C (NPR-C) was identified in Shandong and Hubei cohorts. Then rs700926 and other nine tag SNPs were genotyped in four geographically different populations (Shandong, Shaanxi, Hubei and Sichuan cohorts), and 6 SNPs (rs700926, rs1833529, rs2270915, rs17541471, rs3792758 and rs696831) showed stronger association with CAD, regardless of single or combined analysis. We further genotyped rs2270915 and 10 additional tag SNPs in a central China cohort and identified rs12697273 and rs10066436 as the loci associated with CAD. All these positive associations remained significant after adjustment for traditional risk factors of CAD. NPR-C gene SNPs significantly contribute to CAD susceptibility in the Chinese Han population.

引用

页码：33662 / 33674

页数：13

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