Quantifying drug-induced dyskinesias in the arms using digitised spiral-drawing tasks

被引:59
作者
Liu, XG
Carroll, CB
Wang, SY
Zajicek, J
Bain, PG
机构
[1] Univ London Imperial Coll Sci Technol & Med, Movement Disorders & Neurostimulat Grp, Div Neurosci & Psychol Med, Charing Cross Hosp, London W6 8RF, England
[2] Derriford Hosp, Dept Neurol, Plymouth PL6 8DH, Devon, England
[3] Univ Oxford, Physiol Lab, Oxford OX1 2JD, England
关键词
dyskinesia; drawing; Parkinson's disease; arm;
D O I
10.1016/j.jneumeth.2004.10.005
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
In this study, we quantify the severity of drug-induced dyskinesias in the arms of Parkinson's disease (PD) patients using digitised spiral-drawing tasks. Two spiral drawings, namely a circular and a square spiral, are designed to, respectively, represent the continuous and discrete arm motions, and the size of the spiral is decided so that both the distal and proximal arm joints are involved. Fifteen PD patients, average disease duration 14.4 ± 7.4 years, were assessed 30 min after a levodopa challenge whilst performing circular and square spiral-drawing tasks. The velocity of drawing movements was computed and the amplitude of the involuntary dyskinetic movements was measured as the standard deviation of the drawing velocity (SD-DV). The mean amplitude of dyskinetic movements was compared between arms and tasks and was correlated with clinical measures including the Bain dyskinesia scale and the total unified Parkinson's disease rating scale (UPDRS) score. The results showed that there was no statistically significant difference in the amplitude of dyskinesias either between the arms or between the continuous (circular) and discrete (square) spiral drawings in this group of PD patients, but interestingly the interaction between arm and drawing pattern was significant. Significant correlations were found between the magnitude of dyskinesia measured from the spiral-drawing tasks and both the 'on' or 'off' UPDRS and also the Bain dyskinesia scale. We conclude that the drawing tasks may be used to provide an objective method of quantifying the severity of drug-induced dyskinesias in the arm in PD patients. © 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:47 / 52
页数:6
相关论文
共 30 条
[1]   ASSESSING THE IMPACT OF ESSENTIAL TREMOR ON UPPER-LIMB FUNCTION [J].
BAIN, PG ;
MALLY, J ;
GRESTY, M ;
FINDLEY, LJ .
JOURNAL OF NEUROLOGY, 1993, 241 (01) :54-61
[2]  
Brown RG, 1999, ANN NEUROL, V45, P473, DOI 10.1002/1531-8249(199904)45:4<473::AID-ANA9>3.0.CO
[3]  
2-V
[4]  
Burkhard PR, 1999, MOVEMENT DISORD, V14, P754, DOI 10.1002/1531-8257(199909)14:5<754::AID-MDS1007>3.0.CO
[5]  
2-1
[6]   Cannabis for dyskinesia in Parkinson disease - A randomized double-blind crossover study [J].
Carroll, CB ;
Bain, PG ;
Teare, L ;
Liu, X ;
Joint, C ;
Wroath, C ;
Parkin, SG ;
Fox, P ;
Wright, D ;
Hobart, J ;
Zajicek, JP .
NEUROLOGY, 2004, 63 (07) :1245-1250
[7]   Quantification of essential tremor in writing and drawing [J].
Elble, RJ ;
Brilliant, M ;
Leffler, K ;
Higgins, C .
MOVEMENT DISORDERS, 1996, 11 (01) :70-78
[8]   Measurement of ataxic symptoms with a graphic tablet:: standard values in controls and validity in Multiple Sclerosis patients [J].
Erasmus, LP ;
Sarno, S ;
Albrecht, H ;
Schwecht, M ;
Pöllmann, W ;
König, N .
JOURNAL OF NEUROSCIENCE METHODS, 2001, 108 (01) :25-37
[9]   Adaptation of arm trajectory during continuous drawing movements in different dynamic environments [J].
Fukushi, T ;
Ashe, J .
EXPERIMENTAL BRAIN RESEARCH, 2003, 148 (01) :95-104
[10]  
Hall L, 2000, TECH COMMUN, V47, P147