Risk of metachronous peritoneal metastases in patients with pT4a versus pT4b colon cancer: An international multicentre cohort study

被引：32

作者：

Bastiaenen, Vivian P. ^{[1
]}

Aalbers, Arend G. J. ^{[2
]}

Arjona-Sanchez, Alvaro ^{[3
]}

Bellato, Vittoria ^{[4
]}

van der Bilt, Jarmila D. W. ^{[1
,5
]}

D'Hoore, Andre ^{[5
]}

Espinosa-Redondo, Esther ^{[3
]}

Klaver, Charlotte E. L. ^{[1
]}

Nagtegaal, Iris D. ^{[6
]}

van Ramshorst, Bert ^{[7
]}

van Santvoort, Hjalmar C. ^{[7
,8
]}

Sica, Giuseppe S. ^{[4
]}

Snaebjornsson, Petur ^{[9
]}

Wasmann, Karin A. T. G. M. ^{[1
]}

de Wilt, Johannes H. W. ^{[10
]}

Wolthuis, Albert M. ^{[5
]}

Tanis, Pieter J. ^{[1
]}

机构：

[1] Univ Amsterdam, Amsterdam UMC, Canc Ctr Amsterdam, Dept Surg, Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands

[2] Netherlands Canc Inst, Dept Surg, Amsterdam, Netherlands

[3] Reina Sofia Univ Hosp & GE09 Res Peritoneal & Ret, Dept Surg, Unit Surg Oncol, Cordoba, Spain

[4] Univ Hosp Tor Vergata, Dept Surg Sci, Rome, Italy

[5] Univ Hosp Leuven, Dept Abdominal Surg, Leuven, Belgium

[6] Radboud Univ Nijmegen, Med Ctr, Dept Pathol, Nijmegen, Netherlands

[7] St Antonius Hosp, Dept Surg, Nieuwegein, Netherlands

[8] Univ Med Ctr Utrecht, Canc Ctr, Utrecht, Netherlands

[9] Netherlands Canc Inst, Dept Pathol, Amsterdam, Netherlands

[10] Radboud Univ Nijmegen, Med Ctr, Dept Surg, Nijmegen, Netherlands

来源：

EJSO | 2021年 / 47卷 / 09期

关键词：

Locally advanced colon cancer; T4 colon cancer; Peritoneal metastases; Oncological outcomes; Survival; COLORECTAL-CANCER; CURATIVE TREATMENT; CARCINOMATOSIS; SURVIVAL; SURGERY; CHEMOTHERAPY; EPIDEMIOLOGY;

D O I：

10.1016/j.ejso.2021.05.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: With evolving treatment strategies aiming at prevention or early detection of metachro-nous peritoneal metastases (PM), identification of high-risk colon cancer patients becomes increasingly important. This study aimed to evaluate differences between pT4a (peritoneal penetration) and pT4b (invasion of other organs/structures) subcategories regarding risk of PM and other oncological outcomes. Materials and methods: From eight databases deriving from four countries, patients who underwent curative intent treatment for pT4N0-2M0 primary colon cancer were included. Primary outcome was the 5-year metachronous PM rate assessed by Kaplan-Meier analysis. Independent predictors for meta-chronous PM were identified by Cox regression analysis. Secondary endpoints included 5-year local and distant recurrence rates, and 5-year disease free and overall survival (DFS, OS). Results: In total, 665 patients with pT4a and 187 patients with pT4b colon cancer were included. Median follow-up was 38 months (IQR 23-60). Five-year PM rate was 24.7% and 12.2% for pT4a and pT4b cat-egories, respectively (p = 0.005). Independent predictors for metachronous PM were female sex, right-sided colon cancer, peritumoral abscess, pT4a, pN2, R1 resection, signet ring cell histology and post -operative surgical site infections. Five-year local recurrence rate was 14% in both pT4a and pT4b cancer (p = 0.138). Corresponding five-year distant metastases rates were 35% and 28% (p = 0.138). Five-year DFS and OS were 54% vs. 62% (p = 0.095) and 63% vs. 68% (p = 0.148) for pT4a vs. pT4b categories, respectively. Conclusion: Patients with pT4a colon cancer have a higher risk of metachronous PM than pT4b patients. This observation has important implications for early detection and future adjuvant treatment strategies. (c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

引用

页码：2405 / 2413

页数：9

共 28 条

[11] Peritoneal carcinomatosis from colorectal cancer [J].

Jayne, DG ;

Fook, S ;

Loi, C ;

Seow-Choen, F .

BRITISH JOURNAL OF SURGERY, 2002, 89 (12) :1545-1550

[12] Adjuvant hyperthermic intraperitoneal chemotherapy in patients with locally advanced colon cancer (COLOPEC): a multicentre, open-label, randomised trial [J].

Klaver, Charlotte E. L. ;

Wisselink, Daniel D. ;

Punt, Cornelis J. A. ;

Snaebjornsson, Petur ;

Crezee, Johannes ;

Aalbers, Arend G. J. ;

Brandt, Alexandra ;

Bremers, Andre J. A. ;

Burger, Jacobus W. A. ;

Fabry, Hans F. J. ;

Ferenschild, Floris ;

Festen, Sebastiaan ;

van Grevenstein, Wilhelmina M. U. ;

Hemmer, Patrick H. J. ;

de Hingh, Ignace H. J. T. ;

Kok, Niels F. M. ;

Musters, Gijsbert D. ;

Schoonderwoerd, Lotte ;

Tuynman, Jurriaan B. ;

van de Ven, Anthony W. H. ;

van Westreenen, Henderik L. ;

Wiezer, Marinus J. ;

Zimmerman, David D. E. ;

van Zweeden, Annette A. ;

Dijkgraaf, Marcel G. W. ;

Tanis, Pieter J. .

LANCET GASTROENTEROLOGY & HEPATOLOGY, 2019, 4 (10) :761-770

[13] Postoperative abdominal infections after resection of T4 colon cancer increase the risk of intra-abdominal recurrence [J].

Klaver, Charlotte E. L. ;

Wasmann, Karin A. T. G. M. ;

Verstegen, Marlies ;

van der Bilt, Jarmila D. W. ;

Nagtegaal, Iris D. ;

van Ramshorst, Bert ;

Tanis, Pieter J. ;

Wolthuis, Albert M. ;

van Santvoort, Hjalmar C. ;

de Wilt, Johannes H. W. ;

D'Hoore, Andre .

EJSO, 2018, 44 (12) :1880-1888

[14] Locally Advanced Colon Cancer: Evaluation of Current Clinical Practice and Treatment Outcomes at the Population Level [J].

Klaver, Charlotte E. L. ;

Gietelink, Lieke ;

Bemelman, Willem A. ;

Wouters, Michel W. J. M. ;

Wiggers, Theo ;

Tollenaar, Rob A. E. M. ;

Tanis, Pieter J. .

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2017, 15 (02) :181-190

[15] Risk Factors for Peritoneal Recurrence in Stage II to III Colon Cancer [J].

Mayanagi, Shuhei ;

Kashiwabara, Kosuke ;

Honda, Michitaka ;

Oba, Koji ;

Aoyama, Toru ;

Kanda, Mitsuro ;

Maeda, Hiromichi ;

Hamada, Chikuma ;

Sadahiro, Sotaro ;

Sakamoto, Junichi ;

Saji, Shigetoyo ;

Yoshikawa, Takaki .

DISEASES OF THE COLON & RECTUM, 2018, 61 (07) :803-808

[16] Tumour invasiveness, the local and systemic environment and the basis of staging systems in colorectal cancer [J].

Park, J. H. ;

van Wyk, H. ;

Roxburgh, C. S. D. ;

Horgan, P. G. ;

Edwards, J. ;

McMillan, D. C. .

BRITISH JOURNAL OF CANCER, 2017, 116 (11) :1444-1450

[17] The relationship between tumour stroma percentage, the tumour microenvironment and survival in patients with primary operable colorectal cancer [J].

Park, J. H. ;

Richards, C. H. ;

McMillan, D. C. ;

Horgan, P. G. ;

Roxburgh, C. S. D. .

ANNALS OF ONCOLOGY, 2014, 25 (03) :644-651

[18] Epidemiology, Management, and Survival of Peritoneal Carcinomatosis from Colorectal Cancer: A Population-Based Study [J].

Quere, P. ;

Facy, O. ;

Manfredi, S. ;

Jooste, V. ;

Faivre, J. ;

Lepage, C. ;

Bouvier, A. -M. .

DISEASES OF THE COLON & RECTUM, 2015, 58 (08) :743-752

[19] External validation of models predicting the individual risk of metachronous peritoneal carcinomatosis from colon and rectal cancer [J].

Segelman, J. ;

Akre, O. ;

Gustafsson, U. O. ;

Bottai, M. ;

Martling, A. .

COLORECTAL DISEASE, 2016, 18 (04) :378-385

[20] Individualized prediction of risk of metachronous peritoneal carcinomatosis from colorectal cancer [J].

Segelman, J. ;

Akre, O. ;

Gustafsson, U. O. ;

Bottai, M. ;

Martling, A. .

COLORECTAL DISEASE, 2014, 16 (05) :359-367

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