Subclinical hypothyroidism: summary of evidence in 2014

被引：56

作者：

Baumgartner, Christine ^{[1
]}

Blum, Manuel R. ^{[1
]}

Rodondi, Nicolas ^{[1
]}

机构：

[1] Univ Hosp Bern, Inselspital, Dept Gen Internal Med, CH-3010 Bern, Switzerland

来源：

SWISS MEDICAL WEEKLY | 2014年 / 144卷

基金：

瑞士国家科学基金会;

关键词：

subclinical hypothyroidism; thyroid-stimulating hormone; screening; treatment; cardiovascular risk; CORONARY-HEART-DISEASE; THYROID-DYSFUNCTION; CARDIOVASCULAR HEALTH; COGNITIVE FUNCTION; OLDER-ADULTS; LEVOTHYROXINE REPLACEMENT; FUNCTIONAL-CAPACITY; THYROXINE TREATMENT; BODY-COMPOSITION; BLOOD-PRESSURE;

D O I：

10.4414/smw.2014.14058

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Subclinical hypothyroidism, which is defined as elevated thyroid-stimulating hormone (TSH) levels with free thyroxine concentrations within the reference range, is a common disorder that increases with age and affects up to 18% of the elderly, with a higher prevalence in women compared to men. Prospective data have shown an increased risk of coronary heart disease events, heart failure, and cardiovascular mortality among affected adults. Conflicting results have been found on the association between subclinical hypothyroidism and cognitive impairment, depression and the risk of fractures. Management strategies including screening and treatment of subclinical hypothyroidism are still controversial, while the ongoing European randomised controlled trial "TRUST" targets to solve these uncertainties. This narrative review aims to assess current evidence on the clinical aspects, as well as screening and treatment recommendations in adults with subclinical hypothyroidism.

引用

页数：9

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