One-Pot Synthesis of New Pyranopyrazoles via Domino Multicomponent Reaction

An active heterocyclic unite building represented by compound 1,3,4-thiadiazole-2,5-dithiole (1) was prepared through the reaction of carbon disulfide and hydrazine hydrate. This unite building was reacted with hydrazine hydrate to afford the corresponding 2,5-dihydrazino -1,3,4-thiadiazole (2) which then undergoes one-pot catalytic-free multicomponent reaction with malononitrile, substituted aldehyde and ethyl acetoacetate to obtained 2,5-di (3-methyl-4-aryl-pyrano [2,3-c] pyrazole-5-amino-6-cyno-1-yl)-1,3,4-thiadiazole (3-9). All prepared compounds were elucidated by available methods represented by M.P, T.L.C, FT-IR and for some compounds H-1.NMR.