Intrastrain Comparison of the Chemical Composition and Antioxidant Activity of an Edible Mushroom, Pleurotus giganteus, and Its Potent Neuritogenic Properties

被引：21

作者：

Chia-Wei Phan ^{[1
,2
]}

David, Pamela ^{[1
,3
]}

Tan, Yee-Shin ^{[1
,2
]}

Naidu, Murali ^{[1
,3
]}

Wong, Kah-Hui ^{[1
,3
]}

Kuppusamy, Umah Rani ^{[1
,4
]}

Sabaratnam, Vikineswary ^{[1
,2
]}

机构：

[1] Univ Malaya, Inst Biol Sci, Mushroom Res Ctr, Fac Sci, Kuala Lumpur 50603, Malaysia

[2] Univ Malaya, Inst Biol Sci, Fac Sci, Kuala Lumpur 50603, Malaysia

[3] Univ Malaya, Dept Anat, Fac Med, Kuala Lumpur 50603, Malaysia

[4] Univ Malaya, Dept Biomed Sci, Fac Med, Kuala Lumpur 50603, Malaysia

来源：

SCIENTIFIC WORLD JOURNAL | 2014年

关键词：

IN-VITRO ANTIOXIDANT; NEURITE OUTGROWTH; AMINO-ACID; CULTIVATED MUSHROOMS; MEDICINAL MUSHROOMS; WILD MUSHROOMS; FATTY-ACIDS; SAJOR-CAJU; OSTREATUS; EXTRACT;

D O I：

10.1155/2014/378651

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Two strains of Pleurotus giganteus (commercial and wild) were tested for their ability to induce neurite outgrowth in rat pheochromocytoma (PC12) andmouse neuroblastoma-2a (N2a) cells. Treatment with the mushroom extracts resulted in neuronal differentiation and neuronal elongation, but not nerve growth factor (NGF) production. Linoleic acid (4.5-5.0%, w/w) which is a major fatty acid present in the ethanol extract promoted NGF biosynthesis when augmented with low concentration of NGF (5 ng/mL). The two strains of mushroom were found to be high in protein (154-192 g kg(-1)), total polysaccharides, phenolics, and flavonoids as well as vitamins B1, B2, and B3. The total phenolics present in the mushroom extracts were positively correlated to the antioxidant activity (free radical scavenging, ferric reducing power, and lipid peroxidation inhibition). To conclude, P. giganteus could potentially be used in well-balanced diet and as a source of dietary antioxidant to promote neuronal health.

引用

页数：10

共 49 条

[1] Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities [J].