Protective effect of nerolidol on lipopolysaccharide-induced acute lung injury through the inhibition of NF-κB activation by the reduction of p38 MAPK and JNK phosphorylation

被引:21
作者
Chen, Shih-Pin [1 ,2 ]
Su, Chun-Hung [1 ,2 ]
Huang-Liu, Rosa [3 ]
Lee, Min-Wei [4 ]
Chiang, Chen-Yu [5 ]
Chen, Wen-Ying [5 ]
Chen, Chun-Jung [6 ]
Wu, Sheng-Wen [1 ,2 ,9 ]
Kuang, Yu-Hsiang [7 ,8 ]
机构
[1] Chung Shan Med Univ, Sch Med, Dept Internal Med, Taichung, Taiwan
[2] Chung Shan Med Univ Hosp, Dept Internal Med, Taichung, Taiwan
[3] Chung Shan Med Univ, Sch Nutr, Taichung, Taiwan
[4] Natl Chung Hsing Univ, Grad Inst Microbiol & Publ Hlth, Taichung, Taiwan
[5] Natl Chung Hsing Univ, Dept Vet Med, Taichung, Taiwan
[6] Taichung Vet Gen Hosp, Dept Educ & Res, Taichung, Taiwan
[7] Chung Shan Med Univ, Sch Med, Dept Pharmacol, Taichung, Taiwan
[8] Chung Shan Med Univ Hosp, Dept Pharm, 110,Sec 1,Jianguo N Rd, Taichung, Taiwan
[9] Chung Shan Med Univ Hosp, Div Nephrol, Dept Internal Med, Taichung, Taiwan
关键词
Nerolidol; LPS; Acute lung injury; NF-kappa B; p38; MAPK; JNK; ACUTE KIDNEY INJURY; ESSENTIAL OIL; OXIDATIVE STRESS; EXPRESSION; EPIDEMIOLOGY; INFLAMMATION; NEUTROPHILS; ZERUMBONE; SYSTEM; LEAVES;
D O I
10.1016/j.jff.2020.103943
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Acute lung injury (ALI) is a severe syndrome, and there are no effective therapeutic appropriate medicines. Nerolidol, which exists in the essential oils of aromatic plants and flowers, exhibits antioxidative and anti-inflammatory activities. The present study evaluated the potential protective effect of nerolidol in ALI and the related mechanism in lipopolysaccharide (LPS)-treated mice. Here, nerolidol inhibited the LPS-induced neutrophil and other leukocyte infiltration of the alveolar space. LPS increased cytokines, chemokines, and adhesion molecules, and proinflammatory protein production was inhibited by nerolidol. LPS-induced phosphorylation of NF-kappa B p65, p38 MAPK, JNK, ERK were inhibited by nerolidol. The inhibitory concentration of nerolidol for the phosphorylation of NF-kappa B p65 and its upstream factors, p38 MAPK and JNK, was similar to the inflammatory responses of ALI. In conclusion, nerolidol is a potential protective agent in ALI via the inhibition of NF-kappa B activation and its upstream factors phosphorylation of p38 MAPK and JNK.
引用
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页数:7
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