Twofold C-H functionalization:: Palladium-catalyzed ortho arylation of anilides

被引：277
作者：
Brasche, Gordon [1 ]
Garcia-Fortanet, Jorge [1 ]
Buchwald, Stephen L. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 11期
关键词：
D O I：
10.1021/ol800619c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The ortho arylation of anilides to form biphenyls via a twofold C-H functionalization/C-C bond-forming process is described. The oxidative coupling takes place in the presence of 5-10 mol % of Pd(OAC)(2), 10-20 mol % of DMSO, and 4-11 equiv of the aryl substrate in TFA under an oxygen atmosphere. No metal-containing cocatalyst is required.
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收藏
页码：2207 / 2210
页数：4
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