Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression

被引:208
作者
Wendt, Michael K. [1 ]
Tian, Maozhen [1 ]
Schiemann, William P. [1 ]
机构
[1] Case Western Reserve Univ, Div Gen Med Sci Oncol, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA
基金
美国国家卫生研究院;
关键词
Cancer stem cells; Chemoresistance Epithelial-mesenchymal transition; Integrins; Metastasis; Transforming growth factor-beta; Tumor microenvironment; EPITHELIAL-MESENCHYMAL TRANSITION; TRANSFORMING-GROWTH-FACTOR; CELL LUNG-CANCER; GENE-EXPRESSION SIGNATURE; BREAST-CARCINOMA CELLS; MOUSE MAMMARY-TUMORS; REGULATES E-CADHERIN; STEM-CELLS; DRUG-RESISTANCE; FACTOR RECEPTOR;
D O I
10.1007/s00441-011-1199-1
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Transforming growth factor-beta (TGF-beta) is a potent pleiotropic cytokine that regulates mammalian development, differentiation, and homeostasis in essentially all cell types and tissues. TGF-beta normally exerts anticancer activities by prohibiting cell proliferation and by creating cell microenvironments that inhibit cell motility, invasion, and metastasis. However, accumulating evidence indicates that the process of tumorigenesis, particularly that associated with metastatic progression, confers TGF-beta with oncogenic activities, a functional switch known as the "TGF-beta paradox." The molecular determinants governing the TGF-beta paradox are complex and represent an intense area of investigation by researchers in academic and industrial settings. Recent findings link genetic and epigenetic events in mediating the acquisition of oncogenic activity by TGF-beta, as do aberrant alterations within tumor microenvironments. These events coalesce to enable TGF-beta to direct metastatic progression via the stimulation of epithelial-mesenchymal transition (EMT), which permits carcinoma cells to abandon polarized epithelial phenotypes in favor of apolar mesenchymal-like phenotypes. Attempts to deconstruct the EMT process induced by TGF-beta have identified numerous signaling molecules, transcription factors, and microRNAs operant in mediating the initiation and resolution of this complex transdifferentiation event. In addition to its ability to enhance carcinoma cell invasion and metastasis, EMT also endows transitioned cells with stem-like properties, including the acquisition of self-renewal and tumor-initiating capabilities coupled to chemoresistance. Here, we review recent findings that delineate the pathophysiological mechanisms whereby EMT stimulated by TGF-beta promotes metastatic progression and disease recurrence in human carcinomas.
引用
收藏
页码:85 / 101
页数:17
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