Relationship between body mass index, risk of venous thromboembolism and pulmonary embolism: A systematic review and dose-response meta-analysis of cohort studies among four million participants

被引：42

作者：

Rahmani, Jamal ^{[1
]}

Roudsari, Arezoo Haghighian ^{[2
]}

Bawadi, Hiba ^{[3
]}

Thompson, Jacqueline ^{[4
]}

Fard, Razieh Khalooei ^{[5
]}

Clark, Cain ^{[6
]}

Ryan, Paul M. ^{[7
]}

Ajami, Marjan ^{[2
]}

Sakak, Fatemeh Rahimi ^{[5
]}

Salehisahlabadi, Ammar ^{[5
]}

Abdulazeem, Hebatullah M. ^{[8
]}

Jamali, Mohammad Reza ^{[9
]}

Razaz, Jalaledin Mirzay ^{[2
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr & Food Technol, Dept Community Nutr,Student Res Comm, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Sch Nutr Sci & Food Technol, Dept Food & Nutr Policy & Planning, Tehran, Iran

[3] Qatar Univ, Coll Hlth Sci, QU Hlth, Doha, Qatar

[4] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford OX3 7LD, England

[5] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran

[6] Coventry Univ, Ctr Intelligent Healthcare, Coventry CV1 5FB, W Midlands, England

[7] Univ Coll Cork, Sch Med, Cork, Ireland

[8] AICPD, Family Med, Cairo, Egypt

[9] Isfahan Univ Med Sci, Dept Clin Nutr, Students Res Comm, Sch Nutr & Food Sci, Esfahan, Iran

来源：

THROMBOSIS RESEARCH | 2020年 / 192卷

关键词：

Body mass index; Venous thromboembolism; Pulmonary embolism; OBESITY; THROMBOSIS; EPIDEMIOLOGY;

D O I：

10.1016/j.thromres.2020.05.014

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The relationship between body mass index (BMI) and risk of venous thromboembolism (VTE) and pulmonary embolism (PE) is a controversial issue. This dose-response meta-analysis was performed to investigate the association between BMI and risk of VTE and PE incidence based on cohort studies. Method: A comprehensive systematic search was conducted up to August 2019 in MEDLINE/PubMed, SCOPUS, and Cochrane. DerSimonian and Laird random-effects models were run to estimate combined hazard ratios (HRs) with 95% confidence intervals (CIs). Dose-response analysis was also carried out based on BMI values. Results: Eleven articles with 16 arms and 3,910,747 participants were eligible for inclusion in this systematic review and meta-analysis. Pooled results showed a positive association between BMI and risk of VTE in the obese participants compared to participants classified in the normal BMI category (HR: 1.62, 95% CI: 1.29-2.04, I-2 = 95%). Furthermore, results showed a significant association between lower BMI (underweight versus normal BMI category) and reduced risk of PE (HR: 0.80, 95% CI: 0.70-0.92, I-2 = 9%) and higher risk of PE in obese versus normal BMI participants (HR: 2.24, 95% CI: 1.93-2.60, I-2 = 0%). There was a significant linear relationship between BMI and risk of VTE (p < 0.001) and PE (p < 0.001). Conclusions: This systematic review and dose-response meta-analysis with 3,910,747 participants highlights obesity as a significant risk factor related to the incidence of VTE and PE.

引用

页码：64 / 72

页数：9

共 31 条

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