A fine-scale map of recombination rates and hotspots across the human genome

被引：812

作者：

Myers, S ^{[1
]}

Bottolo, L ^{[1
]}

Freeman, C ^{[1
]}

McVean, G ^{[1
]}

Donnelly, P ^{[1
]}

机构：

[1] Univ Oxford, Dept Stat, Oxford OX1 3TG, England

来源：

SCIENCE | 2005年 / 310卷 / 5746期

基金：

英国惠康基金;

关键词：

D O I：

10.1126/science.1117196

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Genetic maps, which document the way in which recombination rates vary over a genome, are an essential tool for many genetic analyses. We present a high-resolution genetic map of the human genome, based on statistical analyses of genetic variation data, and identify more than 25,000 recombination hotspots, together with motifs and sequence contexts that play a role in hotspot activity. Differences between the behavior of recombination rates over large (megabase) and small (kilobase) scales lead us to suggest a two-stage model for recombination in which hotspots are stochastic features, within a framework in which large-scale rates are constrained.

引用

页码：321 / 324

页数：4

共 28 条

[1] Comprehensive human genetic maps: Individual and sex-specific variation in recombination [J].