Vitamin D supplementation in patients with alcoholic liver cirrhosis: a prospective study

被引:26
|
作者
Savic, Zeljka [1 ]
Vracaric, Vladimir [1 ]
Milic, Natasa [2 ]
Niciforovic, Dijana [3 ]
Damjanov, Dragomir [1 ]
Pellicano, Rinaldo [4 ]
Medic-Stojanoska, Milica [5 ]
Abenavoli, Ludovico [6 ]
机构
[1] Univ Novi Sad, Fac Med, Clin Ctr Vojvodina, Clin Gastroenterol & Hepatol, Novi Sad, Serbia
[2] Univ Novi Sad, Fac Med, Dept Pharm, Novi Sad, Serbia
[3] Univ Novi Sad, Fac Med, Clin Ctr Vojvodina, Clin Radiol, Novi Sad, Serbia
[4] Molinette Mauriziano Hosp, Unit Gastroenterol, Turin, Italy
[5] Univ Novi Sad, Clin Ctr Vojvodina, Clin Endocrinol Diabet & Metab Dis, Novi Sad, Serbia
[6] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy
关键词
Liver diseases; Cholecalciferol; Metabolism; Liver cirrhosis; Vitamin D; D DEFICIENCY; DYSFUNCTION; THERAPY;
D O I
10.23736/S0026-4806.18.05723-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND: The liver is involved in the metabolism of vitamin D. The prevalence of osteopenia in alcoholic liver disease (ALD) patients is 34-48%, and the prevalence of osteoporosis is 11-36%. Advanced liver disease is considered a risk factor for the development of osteoporosis. The aim of this study was to establish the relationship between vitamin D level and Child-Pugh score in patients with alcoholic liver cirrhosis (ALC), and to evaluate the effects of oral vitamin D supplementation. METHODS: Seventy male ALC patients in the absence of active alcohol intake were enrolled and their clinical and laboratory data were recorded. A supplementation of cholecalciferol 1000 IU/day was administered. The vitamin D status was analyzed during the study, in patients stratified by Child-Pugh score. RESULTS: The study was completed by fifty patients. At the enrollment, the mean level of vitamin D was 60.73 +/- 28.02, 50.53 +/- 39.52 and 26.71 +/- 12.81 nmol/L, respectively for Child-Pugh score class A, B and C. During vitamin D supplementation it was found in all the patients a significant increase of its levels during the first six months (P<0.05). However, in class C the improvement was consistent also after year (P<0.05). At the end of the study, two of seven patients initially in class C changed in class A, four from class C to B, and one remained in class C (P=0.012). Out of seventeen patients initially in class B, eleven changed to class A, and six remained in class B. CONCLUSIONS: In patients with ALC, higher level of vitamin D level is related with lower Child-Pugh score. The supplementation of 1000 IU/day of vitamin Din these patients was optimal for a period of at least six months. A decrease in the Child-Pugh score was also found, with a redistribution of the patients in different classes.
引用
收藏
页码:352 / 357
页数:6
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