Association between the tumor necrosis factor-α-308 G/A gene polymorphism and migraine

被引：61
|
作者：
Rainero, I
Grimaldi, LME
Salani, G
Valfrè, W
Rivoiro, C
Savi, L
Pinessi, L
机构：
[1] Univ Turin, Dept Neurosci, Neurol Headache Ctr 3, Neuroimmunol Unit, I-10126 Turin, Italy
[2] IRCCS San Raffaele, Dept Neurosci, Milan, Italy
[3] AUSL 2, Dept Neurosci, Caltanisetta, Italy
来源：
NEUROLOGY | 2004年 / 62卷 / 01期
关键词：
D O I：
10.1212/01.WNL.0000101717.16799.8F
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In a group of 299 migraine patients and 306 control subjects, the association of the -308 G/A polymorphism in the tumor necrosis factor-alpha gene (TNFalpha) with the occurrence and clinical characteristics of migraine was tested. Homozygosity for the G allele was associated with an increased risk of migraine (odds ratio [OR] = 2.85, p < 0.001). When the patients were divided into subgroups, the association was confirmed in patients affected by migraine without aura (OR = 3.30, p < 0.001) but not in migraine with aura. These data suggest that the TNFalpha gene or a linked locus significantly modulates the risk for migraine.
引用
收藏
页码：141 / 143
页数：3
相关论文
共 50 条
  • [31] Tumor necrosis factor-α gene polymorphism at position -308 and schizophrenia in the Korean population
    Pae, CU
    Chae, JH
    Bahk, WM
    Han, H
    Jun, TY
    Kim, KS
    Kwon, YS
    Serretti, A
    PSYCHIATRY AND CLINICAL NEUROSCIENCES, 2003, 57 (04) : 399 - 403
  • [32] Possible association between -G308A tumour necrosis factor-α gene polymorphism and major depressive disorder in the Korean population
    Jun, TY
    Pae, CU
    Hoon-Han
    Chae, JH
    Bahk, WM
    Kim, KS
    Serretti, A
    PSYCHIATRIC GENETICS, 2003, 13 (03) : 179 - 181
  • [33] Association between bioactive circulating tumor necrosis factor level and tumor necrosis factor-308 polymorphism gene in rheumatoid arthritis
    Marotte, H.
    Arnaud, B.
    Diasparra, J.
    Pachot, A.
    Mougin, B.
    Miossec, P.
    ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 : A26 - A26
  • [34] Tumor Necrosis Factor-α-308G/A Genetic Polymorphism and the Susceptibility of Posttraumatic Sepsis
    Wu, Ying
    Wu, Chenfang
    Zhang, Siye
    Wu, Diling
    Zhong, Yanjun
    INTERNATIONAL SURGERY, 2019, 104 (5-6) : 291 - 296
  • [35] Association between the G252A Tumor Necrosis Factor-β Gene Polymorphism and Medication-Overuse Headache
    Ishii, Masakazu
    Onaya, Tomomi
    Katoh, Hirotaka
    Kiuchi, Yuji
    Kasai, Hideyo
    Kawamura, Mitsuru
    Shimizu, Shunichi
    JOURNAL OF CLINICAL NEUROLOGY, 2012, 8 (04): : 301 - 304
  • [36] -308 A/G polymorphism in the tumor necrosis factor-α gene influences outcome of etanercept treatment in rheumatoid arthritis.
    Guis, Sandrine, Sr.
    Balandraud, Nathalie
    Bouvenot, Julien
    Auger, Isabelle
    Mugnier, Benedicte
    Toussirot, Eric
    Wendling, Daniel
    Mattei, Jean Pierre
    Tomachot, Benoit
    Legeron, Pierre
    Landt, Olfert
    Roudier, Jean
    Roudier, Chantal
    ARTHRITIS AND RHEUMATISM, 2006, 54 (09): : S231 - S231
  • [37] Association of tumor necrosis factor-α gene polymorphism (-308) and obstructive sleep apnea-hypopnea syndrome.
    Almpanidou, P.
    Hadjigeorgiou, G.
    Gourgoulianis, K.
    Papadimitriou, A.
    HIPPOKRATIA, 2012, 16 (03) : 217 - 220
  • [38] Association between tumor necrosis factor-α gene polymorphism and Sasang constitution in cerebral infarction
    Um, JY
    Lee, JH
    Joo, JC
    Kim, KY
    Lee, EH
    Shin, T
    Hone, SH
    Kim, HM
    AMERICAN JOURNAL OF CHINESE MEDICINE, 2005, 33 (04): : 547 - 557
  • [39] Tumor necrosis factor gene polymorphism in migraine
    Trabace, S
    Brioli, G
    Lulli, P
    Morellini, M
    Giacovazzo, M
    Cicciarelli, G
    Martelletti, P
    HEADACHE, 2002, 42 (05): : 341 - 345
  • [40] Tumor necrosis factor-α-308 gene polymorphism is associated with synthetic hemodialysis graft failure
    Ram, S
    Bass, K
    Abreo, K
    Baier, RJ
    Kruger, TE
    JOURNAL OF INVESTIGATIVE MEDICINE, 2003, 51 (01) : 19 - 26
12345