Association between the tumor necrosis factor-α-308 G/A gene polymorphism and migraine

被引：61
|
作者：
Rainero, I
Grimaldi, LME
Salani, G
Valfrè, W
Rivoiro, C
Savi, L
Pinessi, L
机构：
[1] Univ Turin, Dept Neurosci, Neurol Headache Ctr 3, Neuroimmunol Unit, I-10126 Turin, Italy
[2] IRCCS San Raffaele, Dept Neurosci, Milan, Italy
[3] AUSL 2, Dept Neurosci, Caltanisetta, Italy
来源：
NEUROLOGY | 2004年 / 62卷 / 01期
关键词：
D O I：
10.1212/01.WNL.0000101717.16799.8F
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In a group of 299 migraine patients and 306 control subjects, the association of the -308 G/A polymorphism in the tumor necrosis factor-alpha gene (TNFalpha) with the occurrence and clinical characteristics of migraine was tested. Homozygosity for the G allele was associated with an increased risk of migraine (odds ratio [OR] = 2.85, p < 0.001). When the patients were divided into subgroups, the association was confirmed in patients affected by migraine without aura (OR = 3.30, p < 0.001) but not in migraine with aura. These data suggest that the TNFalpha gene or a linked locus significantly modulates the risk for migraine.
引用
收藏
页码：141 / 143
页数：3
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