Association between the tumor necrosis factor-α-308 G/A gene polymorphism and migraine

被引：61
|
作者：
Rainero, I
Grimaldi, LME
Salani, G
Valfrè, W
Rivoiro, C
Savi, L
Pinessi, L
机构：
[1] Univ Turin, Dept Neurosci, Neurol Headache Ctr 3, Neuroimmunol Unit, I-10126 Turin, Italy
[2] IRCCS San Raffaele, Dept Neurosci, Milan, Italy
[3] AUSL 2, Dept Neurosci, Caltanisetta, Italy
来源：
NEUROLOGY | 2004年 / 62卷 / 01期
关键词：
D O I：
10.1212/01.WNL.0000101717.16799.8F
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In a group of 299 migraine patients and 306 control subjects, the association of the -308 G/A polymorphism in the tumor necrosis factor-alpha gene (TNFalpha) with the occurrence and clinical characteristics of migraine was tested. Homozygosity for the G allele was associated with an increased risk of migraine (odds ratio [OR] = 2.85, p < 0.001). When the patients were divided into subgroups, the association was confirmed in patients affected by migraine without aura (OR = 3.30, p < 0.001) but not in migraine with aura. These data suggest that the TNFalpha gene or a linked locus significantly modulates the risk for migraine.
引用
收藏
页码：141 / 143
页数：3
相关论文
共 50 条
  • [1] Association of tumor necrosis factor-α-308 (G→A) polymorphism and susceptibility to brucellosis
    Reza, Jafari-Shakib
    Alireza, Rafiei
    Mostafa, Ansari
    Alireza, Khalilian
    Mehrdad, Hajilooi
    JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, 2009, 42 (01) : 22 - 26
  • [2] Tumor Necrosis Factor-α Gene Polymorphism (G-308A) and Dilated Cardiomyopathy
    Chen, Min
    Jiang, Yu-Feng
    Yang, Hua-Jia
    Zhang, Nan-Nan
    Rui, Qing
    Zhou, Ya-Feng
    INTERNATIONAL HEART JOURNAL, 2019, 60 (03) : 656 - 664
  • [3] Association between Tumor Necrosis Factor-α 308G/A Gene Polymorphism and Silicosis Susceptibility: A Meta-Analysis
    Li, Zhanzhan
    Xue, Jing
    Yan, Shipeng
    Chen, Peng
    Chen, Lizhang
    PLOS ONE, 2013, 8 (10):
  • [4] Association between-G308A tumor necrosis factor alpha gene polymorphism and schizophrenia
    Boin, F
    Zanardini, R
    Pioli, R
    Altamura, CA
    Maes, M
    Gennarelli, M
    MOLECULAR PSYCHIATRY, 2001, 6 (01) : 79 - 82
  • [5] Association between −G308A tumor necrosis factor alpha gene polymorphism and schizophrenia
    F Boin
    R Zanardini
    R Pioli
    C A Altamura
    M Maes
    M Gennarelli
    Molecular Psychiatry, 2001, 6 : 79 - 82
  • [6] Tumor necrosis factor-α−308 G/A polymorphism in obese Caucasians
    E Brand
    U Schorr
    I Kunz
    E Kertmen
    J Ringel
    A Distler
    AM Sharma
    International Journal of Obesity, 2001, 25 : 581 - 585
  • [7] Tumor necrosis factor-α-308 G/A polymorphism in obese Caucasians
    Brand, E
    Schorr, U
    Kunz, I
    Kertmen, E
    Ringel, J
    Distler, A
    Sharma, AM
    INTERNATIONAL JOURNAL OF OBESITY, 2001, 25 (04) : 581 - 585
  • [8] Lack of association between the-308 polymorphism of the tumor necrosis factor-α gene and the insulin resistance syndrome
    de Silva, B
    Gapstur, SM
    Achenbach, YH
    Schuh, TS
    Kotlar, TJ
    Liu, K
    Lowe, WL
    JOURNAL OF INVESTIGATIVE MEDICINE, 2000, 48 (04) : 236 - 244
  • [9] Polymorphism G-308A in the promoter of the tumor necrosis factor-α gene and its association with the risk of venous thromboembolism
    Horakova, Kristyna
    Chylkova, Alicja
    Kolorz, Michal
    Bartosova, Ladislava
    Pechacek, Vaclav
    Starostka, David
    Wroblova, Katerina
    BLOOD COAGULATION & FIBRINOLYSIS, 2012, 23 (04) : 316 - 319
  • [10] Tumor Necrosis Factor-α (-308G&gt;A) Gene Polymorphism and Its Association with Asthma and Atopy Status
    Razaghian, Anahita
    Parvaneh, Nima
    Amirzargar, Ali Akbar
    Gharagozlou, Mohammad
    IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY, 2023, 22 (04) : 337 - 344
12345