Water-soluble rhodium(II) carboxylate adducts: Cytotoxicity of the new compounds

被引：10

作者：

deSouza, AR ^{[1
]}

Najjar, R ^{[1
]}

Glikmanas, S ^{[1
]}

Zyngier, SB ^{[1
]}

机构：

[1] UNIV SAO PAULO,INST CIENCIAS BIOMED,BR-05508 SAO PAULO,BRAZIL

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1996年 / 64卷 / 01期

关键词：

D O I：

10.1016/0162-0134(95)00227-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rhodium(II) carboxylate (acetate, propionate, and butyrate) adducts with isonicotinic acid (Hisonic) were prepared for study. Elemental analyses and electronic spectroscopy show that the adducts contain two isonicotinic acid ligands coordinated in the axial position at the pyridinic nitrogen. The in vitro (K562 human leukemic cell line) assay and LD10 in mice results, in addition to tests of solubility, suggest that, in the presence of blood lipids or cellular membrane, the adducts dissociate into the parent compounds and the rhodium(II) carboxylate enters the cell to carry out its biological effects.

引用

页码：1 / 5

页数：5

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