The targeted podocyte

被引：66

作者：

Fogo, Agnes B. ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Pathol, Nashville, TN 37232 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2011年 / 121卷 / 06期

关键词：

DIABETIC-NEPHROPATHY; GLOMERULOSCLEROSIS; CELL;

D O I：

10.1172/JCI57935

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The podocyte plays a key role both in maintenance of the glomerular filtration barrier and in glomerular structural integrity. Podocyte injury and loss contribute to proteinuria and progressive sclerosis. Inhibitors of mammalian target of rapamycin (mTOR) have variably decreased or caused proteinuria and sclerosis in human disease and experimental settings. In this issue of the JCI, two interesting studies of podocyte-specific manipulation of the mTOR system shed light on the complexity of this pathway in the podocyte.

引用

页码：2142 / 2145

页数：4

共 22 条

[1] Mouse models of diabetic nephropathy [J].

Alpers, Charles E. ;

Hudkins, Kelly L. .

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2011, 20 (03) :278-284

[2]

DiTullio MT, 1996, MED PEDIATR ONCOL, V26, P325, DOI 10.1002/(SICI)1096-911X(199605)26:5<325::AID-MPO4>3.0.CO

[3]

2-K

[4]

Fatima H, 2011, LAB INVEST, V91, p344A

[5] The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A [J].

Faul, Christian ;

Donnelly, Mary ;

Merscher-Gomez, Sandra ;

Chang, Yoon Hee ;

Franz, Stefan ;

Delfgaauw, Jacqueline ;

Chang, Jer-Ming ;

Choi, Hoon Young ;

Campbell, Kirk N. ;

Kim, Kwanghee ;

Reiser, Jochen ;

Mundel, Peter .

NATURE MEDICINE, 2008, 14 (09) :931-938

[6] Reversal of lesions of diabetic nephropathy after pancreas transplantation [J].

Fioretto, P ;

Steffes, MW ;

Sutherland, DER ;

Goetz, FC ;

Mauer, M .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (02) :69-75

[7] Can glomerulosclerosis be reversed? [J].

Fogo, AB .

NATURE CLINICAL PRACTICE NEPHROLOGY, 2006, 2 (06) :290-291

[8] Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans [J].

Genovese, Giulio ;

Friedman, David J. ;

Ross, Michael D. ;

Lecordier, Laurence ;

Uzureau, Pierrick ;

Freedman, Barry I. ;

Bowden, Donald W. ;

Langefeld, Carl D. ;

Oleksyk, Taras K. ;

Knob, Andrea L. Uscinski ;

Bernhardy, Andrea J. ;

Hicks, Pamela J. ;

Nelson, George W. ;

Vanhollebeke, Benoit ;

Winkler, Cheryl A. ;

Kopp, Jeffrey B. ;

Pays, Etienne ;

Pollak, Martin R. .

SCIENCE, 2010, 329 (5993) :841-845

[9] Role of mTOR in podocyte function and diabetic nephropathy in humans and mice [J].

Goedel, Markus ;

Hartleben, Bjoern ;

Herbach, Nadja ;

Liu, Shuya ;

Zschiedrich, Stefan ;

Lu, Shun ;

Debreczeni-Mor, Andrea ;

Lindenmeyer, Maja T. ;

Rastaldi, Maria-Pia ;

Hartleben, Goetz ;

Wiech, Thorsten ;

Fornoni, Alessia ;

Nelson, Robert G. ;

Kretzler, Matthias ;

Wanke, Ruediger ;

Pavenstaedt, Hermann ;

Kerjaschki, Dontscho ;

Cohen, Clemens D. ;

Hall, Michael N. ;

Rueegg, Markus A. ;

Inoki, Ken ;

Walz, Gerd ;

Huber, Tobias B. .

JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (06) :2197-2209

[10] mTOR and rapamycin in the kidney: signaling and therapeutic implications beyond immunosuppression [J].

Huber, Tobias B. ;

Walz, Gerd ;

Kuehn, E. Wolfgang .

KIDNEY INTERNATIONAL, 2011, 79 (05) :502-511

← 1 2 3 →