Relationship between Physical Parameters of Various Metal Ions and Binding Affinity for Alginate

被引：32

作者：

Idota, Yoko ^{[1
]}

Kogure, Yumi ^{[1
]}

Kato, Takako ^{[1
]}

Yano, Kentaro ^{[1
]}

Arakawa, Hiroshi ^{[1
,2
]}

Miyajima, Chihiro ^{[3
]}

Kasahara, Fumiyoshi ^{[3
]}

Ogihara, Takuo ^{[1
]}

机构：

[1] Takasaki Univ Hlth & Welf, Fac Pharm, 60 Nakaorui Machi, Takasaki, Gunma 3700033, Japan

[2] Kanazawa Univ, Fac Pharm, Inst Med Pharmaceut & Hlth Sci, Kakuma Machi, Kanazawa, Ishikawa 9201192, Japan

[3] Kimica Corp, Chuo Ku, 2-4-1 Yaesu, Tokyo 1040028, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2016年 / 39卷 / 11期

基金：

日本学术振兴会;

关键词：

alginate; toxic metal; binding mechanism; affinity;

D O I：

10.1248/bpb.b16-00127

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We investigated the relationship between the physical parameters of various metal ions, including toxic metal ions, and the binding affinity of these metal ions for alginate (Alg). The binding constant, K, of Sr2+ was the highest among all tested metal ions. The order of K values was: Sr2+>Pb2+>Tb3+>Dy3+>Ca2+>Cd2+> Mg2+>Fe2+>Fe3+>Co2+>Al3+>Ni2+>Cs+>Cu2+>Ag+>Li+>K+. The metal ions showing the highest K values had ionic radii within the range of about 90-120 pm. Moreover, the K values of divalent or trivalent metal ions tended to be higher than those of monovalent ions. The number of binding sites per 1 mg of Alg (n) was highest for K+, followed by Pb2+ and Cs+. The order of affinity (calculated as the product of n and K) was Pb2+>Dy3+ > Tb3+>Sr2+>Ca2+>Mg2+>Cd2+>Fe2+, Fe3+>Cs+>Al3+>Co2+>Ni2+>Cu2+>Ag+>K+>Li+. Our results support the idea that Alg would be effective as an excretion accelerator and/or absorption inhibitor for various toxic metal ions.

引用

页码：1893 / 1896

页数：4

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