In vitro cholinesterase inhibitory activity of some plants used in Iranian traditional medicine

被引：24

作者：

Saeedi, Mina ^{[1
,2
]}

Babaie, Khatereh ^{[3
]}

Karimpour-Razkenari, Elahe ^{[2
]}

Vazirian, Mahdi ^{[3
]}

Akbarzadeh, Tahmineh ^{[2
,4
]}

Khanavi, Mahnaz ^{[2
,3
]}

Hajimahmoodi, Mannan ^{[2
,5
]}

Ardekani, Mohammad Reza Shams ^{[2
]}

机构：

[1] Univ Tehran Med Sci, Med Plants Res Ctr, Fac Pharm, Tehran, Iran

[2] Univ Tehran Med Sci, Persian Med & Pharm Res Ctr, Tehran, Iran

[3] Univ Tehran Med Sci, Dept Pharmacognosy, Fac Pharm, Tehran, Iran

[4] Univ Tehran Med Sci, Dept Med Chem, Fac Pharm, Tehran, Iran

[5] Univ Tehran Med Sci, Dept Drug & Food Control, Fac Pharm, Tehran, Iran

来源：

NATURAL PRODUCT RESEARCH | 2017年 / 31卷 / 22期

关键词：

Cholinesterase inhibitors; Iranian traditional medicine; A; catechu; S; aromaticum; C; chinensis; P; vulgare; I; turpethum; ALZHEIMERS-DISEASE; ACETYLCHOLINESTERASE;

D O I：

10.1080/14786419.2017.1290620

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In this study, in vitro evaluation of cholinesterase inhibitory (ChEI) activity of various plants including betel nuts (Areca catechu L.), clove buds (Syzygium aromaticum L.), aerial parts of dodder (Cuscuta chinensis Lam.), common polypody rhizomes (Polypodium vulgare L.) and turpeth roots (Ipomoea turpethum R.Br.) which were recommended for the treatment of AD symptoms in Iranian Traditional Medicine (ITM) is reported. Among them, aqueous extract of A. catechu L. was found as the most potent anti-AChE (IC50 = 32.00 mu g/mL) and anti-BChE (IC50 = 48.81 +/- 0.1200 mu g/mL) agent. Aqueous extract of betel nuts as AChE inhibitor (IC50 = 32.00 mu g/mL). [GRAPHICS] .

引用

页码：2690 / 2694

页数：5

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