Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

被引：823

作者：

Iozzo, Renato V. ^{[1
,2
]}

Schaefer, Liana ^{[3
]}

机构：

[1] Thomas Jefferson Univ, Sidney Kimmel Med Coll, Kimmel Canc Ctr, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA

[2] Thomas Jefferson Univ, Sidney Kimmel Med Coll, Kimmel Canc Ctr, Canc Cell Biol & Signaling Program, Philadelphia, PA 19107 USA

[3] Klinikum Univ Frankfurt, Pharmazentrum Frankfurt ZAFES, Inst Allgemeine Pharmakol & Toxikol, Frankfurt, Germany

来源：

MATRIX BIOLOGY | 2015年 / 42卷

基金：

美国国家卫生研究院;

关键词：

Proteoglycan; Glycosaminoglycan; Cancer growth; Angiogenesis; Growth factor modulation; LEUCINE-RICH PROTEOGLYCANS; EPIDERMAL-GROWTH-FACTOR; HEPARAN-SULFATE PROTEOGLYCAN; CORNEAL KERATAN SULFATE; PERLECAN PROTEIN CORE; COLLAGEN TYPE-I; BASEMENT-MEMBRANE COMPONENTS; DENSITY-LIPOPROTEIN-RECEPTOR; MULTIPLE SIGNALING PATHWAYS; OXYGEN-GLUCOSE DEPRIVATION;

D O I：

10.1016/j.matbio.2015.02.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We provide a comprehensive classification of the proteoglycan gene families and respective protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular location, overall gene/protein homology, and the utilization of specific protein modules within their respective protein cores. These three signatures were utilized to design four major classes of proteoglycans with distinct forms and functions: the intracellular, cell-surface, pericellular and extracellular proteoglycans. The proposed nomenclature encompasses forty-three distinct proteoglycan-encoding genes and many alternatively-spliced variants. The biological functions of these four proteoglycan families are critically assessed in development, cancer and angiogenesis, and in various acquired and genetic diseases where their expression is aberrant. (C) 2015 Published by Elsevier B.V.

引用

页码：11 / 55

页数：45

共 614 条

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