Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice

被引：4
|
作者：
Su, Ping [1 ]
Zhai, Dongxu [1 ]
Wong, Albert H. C. [1 ,2 ,4 ,5 ]
Liu, Fang [1 ,2 ,3 ,4 ]
机构：
[1] Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Res Inst, 250 Coll St, Toronto, ON M5T 1R8, Canada
[2] Univ Toronto, Dept Psychiat, Toronto, ON M5T 1R8, Canada
[3] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada
[4] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A8, Canada
[5] Univ Toronto, Fac Med, Dept Pharmacol, Toronto, ON M5S 1A8, Canada
来源：
MOLECULAR BRAIN | 2022年 / 15卷 / 01期
关键词：
Angiotensin-converting enzyme 2 (ACE2); COVID-19; Interfering peptide; SARS-CoV-2; Viral entry; RECEPTOR COMPLEX; NMDA RECEPTOR; SPIKE PROTEIN; INFECTION; TMPRSS2; INHIBITION; FUSION; GENE; ACE2;
D O I：
10.1186/s13041-022-00956-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that has caused a global pandemic Coronavirus Disease 2019 (COVID-19). Currently, there are no effective treatments specifically for COVID-19 infection. The initial step in SARS-CoV-2 infection is attachment to the angiotensin-converting enzyme 2 (ACE2) on the cell surface. We have developed a protein peptide that effectively disrupts the binding between the SARS-CoV-2 spike protein and ACE2. When delivered by nasal spray, our peptide prevents SARS-CoV-2 spike protein from entering lung and olfactory bulb cells of mice expressing human ACE2. Our peptide represents a potential novel treatment and prophylaxis against COVID-19.
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页数：13
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