Child Health, Developmental Plasticity, and Epigenetic Programming

被引：448

作者：

Hochberg, Z. ^{[1
,2
,3
]}

Feil, R. ^{[4
]}

Constancia, M. ^{[5
]}

Fraga, M. ^{[6
]}

Junien, C. ^{[7
]}

Carel, J. -C. ^{[8
]}

Boileau, P. ^{[9
]}

Le Bouc, Y. ^{[10
]}

Deal, C. L. ^{[11
]}

Lillycrop, K. ^{[12
]}

Scharfmann, R. ^{[13
]}

Sheppard, A. ^{[14
]}

Skinner, M. ^{[15
]}

Szyf, M. ^{[16
]}

Waterland, R. A. ^{[17
]}

Waxman, D. J. ^{[18
]}

Whitelaw, E. ^{[19
]}

Ong, K. ^{[20
]}

Albertsson-Wikland, K. ^{[21
]}

机构：

[1] Technion Israel Inst Technol, Rambam Med Ctr, IL-31096 Haifa, Israel

[2] Technion Israel Inst Technol, Rappaport Fac Med, IL-31096 Haifa, Israel

[3] Technion Israel Inst Technol, Res Inst, IL-31096 Haifa, Israel

[4] CNRS, Inst Mol Genet, F-34293 Montpellier, France

[5] Univ Cambridge, Dept Obstet & Gynecol, Metab Res Labs, Cambridge CB3 9EF, England

[6] Univ Oviedo, Ctr Nacl Biotecnol, Oviedo 33003, Spain

[7] Hosp Ambroise Pare, F-78352 Jouy En Josas, France

[8] Hop Robert Debre, INSERM, U690, F-75019 Paris, France

[9] Univ Paris 11, Neonatal Intens Care Unit, Hop Antoine Beclere, F-92140 Clamart, France

[10] Trousseau Hosp, Pediat Endocrine Invest Dept, F-75012 Paris, France

[11] Univ Montreal, Endocrine Serv, Hop St Justine, Montreal, PQ H3G 1A4, Canada

[12] Univ Southampton, Southampton SO17 1BJ, Hants, England

[13] Univ Paris 05, Res Ctr Growth & Signaling, INSERM, U845, F-75005 Paris, France

[14] Univ Auckland, Liggins Inst, Auckland 1010, New Zealand

[15] Washington State Univ, Sch Mol Biosci, Pullman, WA 99164 USA

[16] McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ H2X 3P8, Canada

[17] Baylor Coll Med, USDA, Childrens Nutr Res Ctr, Dept Pediat, Houston, TX 77030 USA

[18] Boston Univ, Dept Biol, Boston, MA 02215 USA

[19] Queensland Inst Med Res, Brisbane, Qld 4006, Australia

[20] Addenbrookes Hosp, Inst Metab Sci, Med Res Council, Epidemiol Unit, Cambridge CB2 0QQ, England

[21] Gothenburg Univ, Goteborg Pediat Res Ctr, Sahlgrenska Acad, S-41345 Gothenburg, Sweden

来源：

ENDOCRINE REVIEWS | 2011年 / 32卷 / 02期

基金：

美国国家卫生研究院; 英国生物技术与生命科学研究理事会;

关键词：

BECKWITH-WIEDEMANN-SYNDROME; GENOME-WIDE ASSOCIATION; ENDOCRINE DISRUPTOR VINCLOZOLIN; HISTONE DEACETYLASE INHIBITORS; GROWTH-HORMONE-SECRETION; IN-VITRO FERTILIZATION; ASSISTED REPRODUCTIVE TECHNOLOGY; DIETARY-PROTEIN RESTRICTION; IMPRINTED GENE METHYLATION; X-CHROMOSOME INACTIVATION;

D O I：

10.1210/er.2009-0039

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Plasticity in developmental programming has evolved in order to provide the best chances of survival and reproductive success to the organism under changing environments. Environmental conditions that are experienced in early life can profoundly influence human biology and long-term health. Developmental origins of health and disease and life-history transitions are purported to use placental, nutritional, and endocrine cues for setting long-term biological, mental, and behavioral strategies in response to local ecological and/or social conditions. The window of developmental plasticity extends from preconception to early childhood and involves epigenetic responses to environmental changes, which exert their effects during life-history phase transitions. These epigenetic responses influence development, cell-and tissue-specific gene expression, and sexual dimorphism, and, in exceptional cases, could be transmitted transgenerationally. Translational epigenetic research in child health is areiterative process that ranges from research in the basic sciences, preclinical research, and pediatric clinical research. Identifying the epigenetic consequences of fetal programming creates potential applications in clinical practice: the development of epigenetic biomarkers for early diagnosis of disease, the ability to identify susceptible individuals at risk for adult diseases, and the development of novel preventive and curative measures that are based on diet and/or novel epigenetic drugs. (Endocrine Reviews 32: 159-224, 2011)

引用

页码：159 / 224

页数：66

共 551 条

[1] IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation [J].

Abuzzahab, MJ ;

Schneider, A ;

Goddard, A ;

Grigorescu, F ;

Lautier, C ;

Keller, E ;

Kiess, W ;

Klammt, J ;

Kratzsch, J ;

Osgood, D ;

Pfäffle, R ;

Raile, K ;

Seidel, B ;

Smith, RJ ;

Chernausek, SD ;

Frank, GR ;

Kaplowitz, PB ;

Pescovitz, OH ;

Smith, EP .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (23) :2211-2222

[2] Transgenerational induction of defences in animals and plants [J].

Agrawal, AA ;

Laforsch, C ;

Tollrian, R .

NATURE, 1999, 401 (6748) :60-63

[3]

Ahuja N, 1998, CANCER RES, V58, P5489

[4] The non-inherited maternal HLA haplotype affects the risk for type 1 diabetes [J].

Akesson, K. ;

Carlsson, A. ;

Ivarsson, S. -A. ;

Johansson, C. ;

Weidby, B. -M. ;

Ludvigsson, J. ;

Gustavsson, B. ;

Lernmark, A. ;

Kockum, I. .

INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2009, 36 (01) :1-8

[5] Epigenetics and the germline [J].

Allegrucci, C ;

Thurston, A ;

Lucas, E ;

Young, L .

REPRODUCTION, 2005, 129 (02) :137-149

[6]

Allis C.D., 2007, Epigenetics, P23

[7] Incomplete penetrance of susceptibility genes for MHC-determined immunoglobulin deficiencies in monozygotic twins discordant for type I diabetes [J].

Alper, Chester A. ;

Husain, Zaheed ;

Larsen, Charles E. ;

Dubey, Devendra P. ;

Stein, Rosanne ;

Day, Caitlin ;

Baker, Alissa ;

Beyan, Huriya ;

Hawa, Mohammed ;

Ola, Thomas O. ;

Leslie, R. David .

JOURNAL OF AUTOIMMUNITY, 2006, 27 (02) :89-95

[8] The discovery and development of proteomic safety biomarkers for the detection of drug-induced liver toxicity [J].

Amacher, David E. .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2010, 245 (01) :134-142

[9] Does serum growth hormone (GH) binding protein reflect human GH receptor function? [J].

Amit, T ;

Youdim, MBH ;

Hochberg, Z .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (03) :927-932

[10] Molecular basis of inherited growth hormone resistance in childhood [J].

Amselem, S ;

Sobrier, ML ;

Dastot, F ;

Duquesnoy, P ;

Duriez, B ;

Goossens, M .

BAILLIERES CLINICAL ENDOCRINOLOGY AND METABOLISM, 1996, 10 (03) :353-369

← 1 2 3 4 5 6 7 8 9 10 →