Successful treatment of refractory immune hemolysis following unrelated cord blood transplant with Campath-1H

被引：16

作者：

Chao, Mwe Mwe ^{[2
]}

Levine, John E. ^{[2
]}

Ferrara, James L. ^{[2
]}

Cooling, Laura ^{[1
]}

Cooke, Kenneth R. ^{[2
]}

Hutchinson, Raymond J. ^{[2
]}

Yanik, Gregory A. ^{[2
]}

机构：

[1] Univ Michigan Hlth Syst, Dept Lab Med & Pathol, Ann Arbor, MI 48109 USA

[2] Univ Michigan Hlth Syst, Dept Pediat, Div Pediat Hematol Oncol & Blood & Marrow Transpl, Ann Arbor, MI 48109 USA

来源：

PEDIATRIC BLOOD & CANCER | 2008年 / 50卷 / 04期

关键词：

campath-1H; cord blood transplantation; Evans syndrome; immune hemolytic anemia; X-linked adrenoleukodystrophy (ALD);

D O I：

10.1002/pbc.21187

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune-mediated hemolytic anemia is a well-recognized complication of hematopoietic stein cell transplantation. We report on a 6-year-old boy with X-linked adrenoleukodystrophy who developed severe delayed alloimmune hemolytic anemia associated with immune-mediated neutropenia and thrombocytopenia following major ABO incompatible unrelated cord blood transplantation. The patient's cytopenias were refractory to treatment with corticosteroids, cyclosporine, intravenous immune globulin, rituximab, and pentostatin. After one course of Campath-1H his hematologic parameters normalized, suggesting that the compound may be an effective therapy for complex immunohematologic disorders complicating hematopoietic stein cell transplantation. The case also emphasizes the importance of T-cells in transplant associated immune cytopenias.

引用

页码：917 / 919

页数：3

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