Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo

被引：83

作者：

Conidi, Andrea ^{[2
]}

Cazzola, Silvia ^{[2
]}

Beets, Karen ^{[2
,3
]}

Coddens, Kathleen ^{[2
]}

Collart, Clara ^{[2
]}

Cornelis, Frederique ^{[2
,3
]}

Cox, Luk ^{[2
,3
]}

Joke, Debruyn ^{[2
]}

Dobreva, Mariya P. ^{[2
,3
]}

Dries, Ruben ^{[2
]}

Esguerra, Camila ^{[2
]}

Francis, Annick ^{[2
]}

Ibrahimi, Abdelilah ^{[2
]}

Kroes, Roel ^{[2
]}

Lesage, Flore ^{[2
]}

Maas, Elke ^{[2
,3
]}

Moya, Ivan ^{[2
,3
]}

Pereira, Paulo N. G. ^{[2
,3
]}

Stappers, Elke ^{[2
]}

Stryjewska, Agata ^{[2
]}

van den Berghe, Veronique ^{[2
]}

Vermeire, Liesbeth ^{[2
]}

Verstappen, Griet ^{[2
]}

Seuntjens, Eve ^{[2
]}

Umans, Lieve ^{[2
,3
]}

Zwijsen, An ^{[2
,3
]}

Huylebroeck, Danny ^{[1
,2
]}

机构：

[1] Univ Leuven, Stem Cell Inst, Lab Mol Biol Celgen, Ctr Human Genet, B-3000 Louvain, Belgium

[2] Univ Leuven VIB, Dept Mol & Dev Genet, B-3000 Louvain, Belgium

[3] Univ Leuven, Ctr Human Genet, Lab Dev Signaling, B-3000 Louvain, Belgium

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2011年 / 22卷 / 5-6期

关键词：

CPSF; Sip1; Smad; Tdp2; Transforming growth factor beta; 5'-TYROSYL DNA PHOSPHODIESTERASE; MEDIATED CONDITIONAL KNOCKOUT; RECEPTOR-ASSOCIATED FACTORS; MULLERIAN DUCT REGRESSION; OF-FUNCTION MUTATIONS; TRANSCRIPTIONAL REPRESSION; SPINOCEREBELLAR ATAXIA; GENETIC INTERACTION; MESODERM FORMATION; LENS DEVELOPMENT;

D O I：

10.1016/j.cytogfr.2011.11.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Signaling by the many ligands of the TGF beta family strongly converges towards only five receptor-activated, intracellular Smad proteins, which fall into two classes i.e. Smad2/3 and Smad1/5/8, respectively. These Smads bind to a surprisingly high number of Smad-interacting proteins (SIPs), many of which are transcription factors (TFs) that co-operate in Smad-controlled target gene transcription in a cell type and context specific manner. A combination of functional analyses in vivo as well as in cell cultures and biochemical studies has revealed the enormous versatility of the Smad proteins. Smads and their SIPs regulate diverse molecular and cellular processes and are also directly relevant to development and disease. In this survey, we selected appropriate examples on the BMP-Smads, with emphasis on Smad1 and Smad5, and on a number of SIPs, i.e. the CPSF subunit Smicl, Ttrap (Tdp2) and Sip1 (Zeb2, Zfhx1b) from our own research carried out in three different vertebrate models. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：287 / 300

页数：14

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