A cluster of four cases of meningococcal disease in a single nuclear family

被引：8
作者：
Acheson, P. [1 ]
Barron, R. [2 ]
Borrow, R. [3 ]
Gray, S. [4 ]
Marodi, C. [5 ]
Ramsay, M. [6 ]
Waller, J. [1 ]
Flood, T. [7 ]
机构：
[1] Hlth Protect Agcy NE, NE Hlth Protect Unit, Newcastle Upon Tyne NE1 4WH, Tyne & Wear, England
[2] S Tees Hosp NHS Fdn Trust, Dept Paediat, Middlesbrough, Cleveland, England
[3] Hlth Protect Agcy, Vaccine Evaluat Unit, Manchester, Lancs, England
[4] Hlth Protect Agcy, Meningococcal Reference Unit, Manchester, Lancs, England
[5] S Tees Hosp NHS Fdn Trust, Dept Clin Microbiol, Middlesbrough, Cleveland, England
[6] Hlth Protect Agcy, Hlth Protect Serv Colindale, London, England
[7] Newcastle Upopn Tyne Hosp NHS Fdn Trust, Dept Paediat Immunol & Infect Dis, Newcastle Upon Tyne, Tyne & Wear, England
来源：
ARCHIVES OF DISEASE IN CHILDHOOD | 2012年 / 97卷 / 03期
关键词：
COMPLEMENT DEFICIENCY; HOUSEHOLD CONTACTS;
D O I：
10.1136/archdischild-2011-301074
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
A cluster of four confirmed cases of meningococcal disease was seen in the same nuclear family across a 15-week period. The cases were three siblings and a parent and all recovered well. The first case was confirmed by meningococcal PCR only but the subsequent three cases were due to indistinguishable strains of serogroup B (B:NT:P1.19-1, 15-11). Contact tracing was initially undertaken and reviewed in detail after each subsequent case. Antibiotic prophylaxis was administered to close family contacts on three separate occasions, including switching of antibiotic agents, with good compliance. Subsequent investigation of the family has not revealed any obvious immunological problem and no further significant infections have been recognised. A cluster of meningococcal disease of this nature and timescale is highly unusual. Details of the cluster, investigation and implications for health protection practice are discussed.
引用
收藏
页码：248 / 249
页数：2
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