IMPROVED ANTI-TUMOR ACTIVITY OF NEXT-GENERATION TCR-ENGINEERED T CELLS THROUGH CD8 CO-EXPRESSION

被引:2
|
作者
Bajwa, Gagan [1 ]
Gunesch, Justin [1 ]
Azoulay-Alfaguter, Inbar [1 ]
Mata, Melinda [1 ]
Mohamed, Ali [1 ]
Kalra, Mamta [1 ]
Walter, Steffen [1 ]
机构
[1] Immat US Inc, Houston, TX USA
关键词
D O I
10.1136/jitc-2021-SITC2021.163
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
163
引用
收藏
页码:A173 / A173
页数:1
相关论文
共 50 条
  • [1] Enhancing Efficacy of TCR-engineered CD4+ T Cells Via Coexpression of CD8α
    Anderson, Victoria E.
    Brilha, Sara S.
    Weber, Anika M.
    Pachnio, Annette
    Wiedermann, Guy E.
    Dauleh, Sumaya
    Ahmed, Tina
    Pope, George R.
    Quinn, Laura L.
    Docta, Roslin Y.
    Quattrini, Adriano
    Masters, Siobhan
    Cartwright, Neil
    Viswanathan, Preetha
    Melchiori, Luca
    Rice, Louise V.
    Sevko, Alexandra
    Gueguen, Claire
    Saini, Manoj
    Tavano, Barbara
    Abbott, Rachel J. M.
    Silk, Jonathan D.
    Laugel, Bruno
    Sanderson, Joseph P.
    Gerry, Andrew B.
    JOURNAL OF IMMUNOTHERAPY, 2023, 46 (04) : 132 - 144
  • [2] ENHANCEMENT OF TCR-ENGINEERED T-CELLS TARGETING MAGE-A4 ANTIGEN BY CO-EXPRESSION OF CD8α AND INHIBITION OF AKT SIGNALING DURING EX VIVO T-CELL EXPANSION
    Schmidt, Emily
    Mardilovich, Katerina
    Bath, Natalie
    Betts, Gareth
    Spinner, William
    Sun, Kathryn
    Donaldson, Ian
    McAlpine, Cheryl
    Luke, Raymond
    Navenot, Jean-Marc
    Sanderson, Joseph
    Bassett, Phil
    Evans, Chris
    Miller, Karen
    Lin, Quan
    Dudley, Mark
    Tipping, Alex
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A401 - A401
  • [3] Tcf-1 protects anti-tumor TCR-engineered CD8+ T-cells from GzmB mediated self-destruction
    Brendan Zangari
    Takemasa Tsuji
    Junko Matsuzaki
    Hemn Mohammadpour
    Cheryl Eppolito
    Sebastiano Battaglia
    Fumito Ito
    Thinle Chodon
    Richard Koya
    A. J. Robert McGray
    Kunle Odunsi
    Cancer Immunology, Immunotherapy, 2022, 71 : 2881 - 2898
  • [4] Tcf-1 protects anti-tumor TCR-engineered CD8+ T-cells from GzmB mediated self-destruction
    Zangari, Brendan
    Tsuji, Takemasa
    Matsuzaki, Junko
    Mohammadpour, Hemn
    Eppolito, Cheryl
    Battaglia, Sebastiano
    Ito, Fumito
    Chodon, Thinle
    Koya, Richard
    McGray, A. J. Robert
    Odunsi, Kunle
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2022, 71 (12) : 2881 - 2898
  • [5] Anti-tumor response in T cells with CD8 independent high affinity TCR remains unaffected with aging
    Kesarwani, Pravin
    Kristina, Andrijauskaite
    Rubinstein, Mark
    Mehrotra, Shikhar
    JOURNAL OF IMMUNOLOGY, 2014, 192
  • [6] Enhanced activity of second-generation MAGE-A4 SPEAR T-cells through co-expression of a CD8α homodimer
    Anderson, Victoria E.
    Weber, Anika M.
    Wiedermann, Guy E.
    Pachnio, Anette
    Dauleh, Sumaya
    Ahmed, Tina
    Docta, Roslin Y.
    Quattrini, Adriano
    Pope, George
    Quinn, Laura
    Ashton, Thomas M.
    Tunbridge, Helen M.
    Sanderson, Joseph P.
    Gerry, Andrew B.
    CANCER RESEARCH, 2019, 79 (13)
  • [7] TCR-induced FOXP3 expression by CD8+ T cells impairs their anti-tumor activity
    Lozano, Teresa
    Conde, Enrique
    Martin-Otal, Celia
    Navarro, Flor
    Lasarte-Cia, Aritz
    Nasrallah, Rabab
    Alignani, Diego
    Gorraiz, Marta
    Sarobe, Pablo
    Romero, Juan P.
    Vilas, Amaia
    Roychoudhuri, Rahul
    Hervas-Stubbs, Sandra
    Casares, Noelia
    Lasarte, Juan Jose
    CANCER LETTERS, 2022, 528 : 45 - 58
  • [8] PGC-1α engineered CD8 T cell for enhanced anti-tumor immunity
    Dumauthioz, Nina
    Tschumi, Benjamin
    Wenes, Mathias
    Wang, Haiping
    Franco, Fabien
    Lopez-Mejia, Isabel
    Fajas, Lluis
    Ho, Ping-Chih
    Donda, Alena
    Romero, Pedro
    Zhang, Lianjun
    SWISS MEDICAL WEEKLY, 2019, : 23S - 24S
  • [9] Anti-tumor effects of endogenous prostate cancer-specific CD8 T cells in a murine TCR transgenic model
    Bruno, Tullia C.
    Rothwell, Cristin
    Grosso, Joseph F.
    Getnet, Derese
    Yen, Hung Rong
    Durham, Nicholas M.
    Netto, George
    Pardoll, Drew M.
    Drake, Charles G.
    PROSTATE, 2012, 72 (05): : 514 - 522
  • [10] Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity
    Qiang Feng
    Zhida Liu
    Xuexin Yu
    Tongyi Huang
    Jiahui Chen
    Jian Wang
    Jonathan Wilhelm
    Suxin Li
    Jiwon Song
    Wei Li
    Zhichen Sun
    Baran D. Sumer
    Bo Li
    Yang-Xin Fu
    Jinming Gao
    Nature Communications, 13