A new efficient synthesis of 3-(4-pyridinyl)methylindoles

被引：18

作者：

Zhou, P ^{[1
]}

Li, YF ^{[1
]}

Meagher, KL ^{[1
]}

Mewshaw, RG ^{[1
]}

Harrison, BL ^{[1
]}

机构：

[1] Wyeth Ayerst Res, Chem Sci, Princeton, NJ 08543 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 42期

关键词：

D O I：

10.1016/S0040-4039(01)01525-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new efficient method for the preparation of 3-(4-pyridinyl)methylindoles has been developed. The new method involves coupling of indoles with 4-pyidinecarboxaldehyde to give 3-indolyl 4-pyridinyl methanols, which upon treatment xvith tricthylsilane in the presence of trifluoroacetic acid afford 3-(4-pyridinyl)methylindoles in 64-76% overall yield. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：7333 / 7335

页数：3

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