Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barre Syndrome

被引：22

作者：

Lynch, Rebecca M. ^{[1
]}

Mantus, Grace ^{[1
]}

Encinales, Liliana ^{[2
]}

Pacheco, Nelly ^{[2
]}

Li, Guangzhao ^{[1
]}

Porras, Alexandra ^{[3
]}

Mendoza, Alejandro R. ^{[3
]}

Peng, Jin ^{[1
]}

Rengifo-Pardo, Monica ^{[4
]}

Cruz, Magelda Montoya ^{[5
]}

Harris, Eva ^{[5
]}

Bethony, Jeff M. ^{[1
]}

Simon, Gary L. ^{[6
]}

Chang, Aileen Y. ^{[6
]}

机构：

[1] George Washington Univ, Dept Microbiol Immunol & Trop Med, Washington, DC USA

[2] Allied Res Soc LLC, Dept Med, Baranquilla, Colombia

[3] Univ El Bosque, Grp Med Comunitaria, Bogota, Colombia

[4] George Washington Univ, Dept Dermatol, Washington, DC USA

[5] Univ Calif Berkeley, Sch Publ Hlth, Div Infect Dis & Vaccinol, Berkeley, CA 94720 USA

[6] George Washington Univ, Dept Med, Washington, DC USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2019年 / 219卷 / 01期

关键词：

Guillain-Barre syndrome; neutralizing antibody; flavivirus; Zika; dengue; VIRUS-INFECTION; CUCUTA;

D O I：

10.1093/infdis/jiy466

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of neutralizing antibodies in Zika-induced Guillain-Barre syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared with uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared with non-GBS ZIKV-infected controls. These data suggest that high neutralizing antibody titers to DENV and to ZIKV are associated with GBS during ZIKV infection.

引用

页码：26 / 30

页数：5

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