Messenger RNA Modifications in Plants

被引：95

作者：

Shen, Lisha ^{[1
]}

Liang, Zhe ^{[2
]}

Wong, Chui Eng ^{[1
,2
]}

Yu, Hao ^{[1
,2
]}

机构：

[1] Natl Univ Singapore, Temasek Life Sci Lab, 1 Res Link, Singapore 117604, Singapore

[2] Natl Univ Singapore, Dept Biol Sci, 14 Sci Dr 4, Singapore 117543, Singapore

来源：

TRENDS IN PLANT SCIENCE | 2019年 / 24卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

SINGLE-NUCLEOTIDE-RESOLUTION; MAPPING REVEALS; NUCLEAR-RNA; N-6-METHYLADENOSINE RNA; GENE-EXPRESSION; YTH DOMAIN; METHYLATION; ARABIDOPSIS; URIDYLATION; 5-METHYLCYTOSINE;

D O I：

10.1016/j.tplants.2019.01.005

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Over 160 distinct RNA modifications are known and collectively termed the epitranscriptome. Some of these modifications have been discovered in mRNA, uncovering a new layer of gene regulation. Transcriptome-wide mapping of epitranscriptomic codes and the discovery of their writers, erasers, and readers that dynamically install, remove, and interpret RNA modifications, respectively, are fundamental to understanding the epitranscriptome. Recent technologies have enabled the transcriptome-wide profiling of several mRNA modifications in Arabidopsis thaliana, providing key insights into regulating these modifications and their effects on plant development. Here we review technological innovations and recent progress in epitranscriptomics, with specific focus on N-6-methyladenosine (m(6)A), 5-methylcytosine (m(5)C), uridylation, and their roles in multiple aspects of plant development.

引用

页码：328 / 341

页数：14

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