Comparative Study of the Levels of IL-1β, IL-4, IL-8, TNFα, and IFNγ in Stable Course and Exacerbation of Chronic Obstructive Pulmonary Disease of Varying Severity

被引：12
作者：
Kubysheva, N., I [1 ]
Postnikova, L. B. [2 ]
Soodaeva, S. K. [3 ]
Novikov, D., V [4 ]
Eliseeva, T., I [5 ]
Novikov, V. V. [4 ,6 ]
Karaulov, A., V [7 ]
机构：
[1] Kazan Volga Reg Fed Univ, Kazan, Russia
[2] City Clin Hosp 38, Nizhnii Novgorod, Russia
[3] Fed Med Biol Agcy Russia, Res Inst Pulmonol, Moscow, Russia
[4] Fed Serv Supervis Consumer Rights Protect & Human, IN Blokhina Nizhny Novgorod Res Inst Epidemiol &, Nizhnii Novgorod, Russia
[5] Privolzhsk Res Med Univ, Minist Hlth Russian Federat, Nizhnii Novgorod, Russia
[6] Natl Res Lobachevsky State Univ Nizhny Novgorod, Nizhnii Novgorod, Russia
[7] Sechenov Univ, Minist Hlth Russian Federat, IM Sechenov Moscow State Med Univ 1, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2022年 / 173卷 / 06期
关键词：
cytokines; chronic obstructive pulmonary disease (COPD); inflammation; bronchial obstruction; ASTHMA;
D O I：
10.1007/s10517-022-05622-z
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In patients with chronic obstructive pulmonary disease, the levels of cytokines IL-1 beta, IL-4, IL-8, TNF alpha, and IFN gamma depended on the degree of bronchial obstruction and severity and period of the disease. The maximum levels of IL-4, IL-8, and TNF alpha were observed in severe chronic obstructive pulmonary disease during exacerbation. The highest concentration of IL-1 beta and IFN gamma were recorded during activation of inflammation in patients with moderate bronchial obstruction. The revealed correlations between the tested cytokines and spirometry parameters make it possible to consider the levels of these proteins as quantitative markers of systemic inflammation progression.
引用
收藏
页码：745 / 748
页数：4
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