Comparative Study of the Levels of IL-1β, IL-4, IL-8, TNFα, and IFNγ in Stable Course and Exacerbation of Chronic Obstructive Pulmonary Disease of Varying Severity

被引：12
作者：
Kubysheva, N., I [1 ]
Postnikova, L. B. [2 ]
Soodaeva, S. K. [3 ]
Novikov, D., V [4 ]
Eliseeva, T., I [5 ]
Novikov, V. V. [4 ,6 ]
Karaulov, A., V [7 ]
机构：
[1] Kazan Volga Reg Fed Univ, Kazan, Russia
[2] City Clin Hosp 38, Nizhnii Novgorod, Russia
[3] Fed Med Biol Agcy Russia, Res Inst Pulmonol, Moscow, Russia
[4] Fed Serv Supervis Consumer Rights Protect & Human, IN Blokhina Nizhny Novgorod Res Inst Epidemiol &, Nizhnii Novgorod, Russia
[5] Privolzhsk Res Med Univ, Minist Hlth Russian Federat, Nizhnii Novgorod, Russia
[6] Natl Res Lobachevsky State Univ Nizhny Novgorod, Nizhnii Novgorod, Russia
[7] Sechenov Univ, Minist Hlth Russian Federat, IM Sechenov Moscow State Med Univ 1, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2022年 / 173卷 / 06期
关键词：
cytokines; chronic obstructive pulmonary disease (COPD); inflammation; bronchial obstruction; ASTHMA;
D O I：
10.1007/s10517-022-05622-z
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In patients with chronic obstructive pulmonary disease, the levels of cytokines IL-1 beta, IL-4, IL-8, TNF alpha, and IFN gamma depended on the degree of bronchial obstruction and severity and period of the disease. The maximum levels of IL-4, IL-8, and TNF alpha were observed in severe chronic obstructive pulmonary disease during exacerbation. The highest concentration of IL-1 beta and IFN gamma were recorded during activation of inflammation in patients with moderate bronchial obstruction. The revealed correlations between the tested cytokines and spirometry parameters make it possible to consider the levels of these proteins as quantitative markers of systemic inflammation progression.
引用
收藏
页码：745 / 748
页数：4
相关论文
共 50 条
[21]   Circulating levels of IL-2, IL-4, TNF-α, IFN-γ, and C-reactive protein are not associated with severity of COVID-19 symptoms [J].
Luo, Wen ;
Zhang, Jia-Wen ;
Zhang, Wei ;
Lin, Yuan-Long ;
Wang, Qi .
JOURNAL OF MEDICAL VIROLOGY, 2021, 93 (01) :89-91
[22]   Serum IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ levels in drug-free, comorbidity-free obsessive-compulsive disorder patients [J].
Erbay, Lale Gonenir ;
Akti Kavuran, Nursel ;
Taskapan, Cagatay ;
Ince, Lara Utku ;
Yologlu, Saim ;
Temelli, Husniye Gul ;
Unal, Suheyla .
ANADOLU PSIKIYATRI DERGISI-ANATOLIAN JOURNAL OF PSYCHIATRY, 2018, 19 (02) :157-162
[23]   Revelation of the IFNα, IL-10, IL-8 and IL-1β as promising biomarkers reflecting immuno-pathological mechanisms in porcine Huntington's disease model [J].
Valekova, Ivona ;
Jarkovska, Karla ;
Kotrcova, Eva ;
Bucci, John ;
Ellederova, Zdenka ;
Juhas, Stefan ;
Motlik, Jan ;
Gadher, Suresh Jivan ;
Kovarova, Hana .
JOURNAL OF NEUROIMMUNOLOGY, 2016, 293 :71-81
[24]   The prognostic importance of serum IL-1β, IL-6, IL-8 and TNF-α levels compared to trauma scoring systems for early mortality in children with blunt trauma [J].
Ozturk, Hayrettin ;
Yagmur, Yusuf ;
Ozturk, Hulya .
PEDIATRIC SURGERY INTERNATIONAL, 2008, 24 (02) :235-239
[25]   Effects of L-NAME and timolol on aqueous IL-1β, IL-6 IL-8, TNF-α and NO levels after Nd:YAG laser iridotomy in rabbits [J].
Er, H ;
Doganay, S ;
Evereklioglu, C ;
Cekmen, M ;
Daglioglu, MC ;
Isci, N .
EUROPEAN JOURNAL OF OPHTHALMOLOGY, 2002, 12 (04) :281-286
[26]   The prognostic importance of serum IL-1β, IL-6, IL-8 and TNF-α levels compared to trauma scoring systems for early mortality in children with blunt trauma [J].
Hayrettin Ozturk ;
Yusuf Yagmur ;
Hulya Ozturk .
Pediatric Surgery International, 2008, 24 :235-239
[27]   Predicting Outcomes After Blunt Chest Trauma-Utility of Thoracic Trauma Severity Score, Cytokines (IL-1β, IL-6, IL-8, IL-10, and TNF-α), and Biomarkers (vWF and CC-16) [J].
Bagaria, Vivek ;
Mathur, Purva ;
Madan, Karan ;
Kumari, Minu ;
Sagar, Sushma ;
Gupta, Amit ;
Soni, Kapil Dev ;
Bhattacharjee, Hemanga ;
Kumar, Subodh .
INDIAN JOURNAL OF SURGERY, 2021, 83 (SUPPL 1) :S113-S119
[28]   Interleukin-18 (IFNγ-inducing factor) induces IL-8 and IL-1β via TNFα production from non-CD14+ human blood mononuclear cells [J].
Puren, AJ ;
Fantuzzi, G ;
Gu, Y ;
Su, MSS ;
Dinarello, CA .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (03) :711-721
[29]   Serum IL-4, IL-12 and TNF-alpha in malaria: A comparative study associating cytokine responses with severity of disease from the Coastal Districts of Odisha [J].
Sarangi A. ;
Mohapatra P.C. ;
Dalai R.K. ;
Sarangi A.K. .
Journal of Parasitic Diseases, 2014, 38 (2) :143-147
[30]   Association of polymorphisms of cytokine genes (IL1B, IL1RN, TNFA, LTA, IL6, IL8, and IL10) with chronic obstructive pulmonary disease [J].
Danilko, K. V. ;
Korytyna, G. F. ;
Akhmadishina, L. Z. ;
Yanbaeva, D. G. ;
Zagidullin, Sh. Z. ;
Victorova, T. V. .
MOLECULAR BIOLOGY, 2007, 41 (01) :22-31
12345