Preparation and biological evaluation of 99mTc-CO-MIBI as myocardial perfusion imaging agent

被引：20

作者：

Chen, Xiangji ^{[1
]}

Guo, Yunhang ^{[1
]}

Zhang, Qiuyan ^{[1
]}

Hao, Guiyang ^{[1
]}

Jia, Hongmei ^{[1
]}

Liu, Boli ^{[1
]}

机构：

[1] Beijing Normal Univ, Coll Chem, Minist Educ, Key Lab Radiopharmaceut, Beijing 100875, Peoples R China

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2008年 / 693卷 / 10期

基金：

中国国家自然科学基金;

关键词：

tricarbonyl technetium; MIBI; myocardial imaging;

D O I：

10.1016/j.jorganchem.2008.02.006

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Tc-99m-Sestamibi has been playing an important role in the cardiac imaging for the last decades. Previously, we reported that [Tc-99m(CO)(3)(MIBI)(3)](+) demonstrated a significant location in myocardium with a lower liver uptake as compared with Tc-99m-Sestamibi. In this work, we found that new [Tc-99m(CO)(2)(MIBI)(4)](+) could be prepared with high radiochemical purity. The inter-transformations between [Tc-99m(CO)(3)(H2O)(MIBI)(2)](+), [Tc-99m(CO)(3)(MIBI)(3)](+), and [Tc-99m(CO)(2)(MIBI)(4)](+) were investigated and biodistribution was performed to evaluate the [(99m) Tc(CO)(2)(MIBI)(4)](+) as a myocardial perfusion imaging agent. The results showed that one more CO was replaced by MIBI slowing down the pharmacokinetics. The structure characterization was performed on their corresponding rhenium complexes, and the results indicated that there were differences between Tc-99m-CO-MIBI and Re-CO-MIBI in preparation and hydrophobic characteristics. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：1822 / 1828

页数：7

共 26 条

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