Nonsense-mediated mRNA decay in Saccharomyces cerevisiae

被引：114

作者：

González, CI

Bhattacharya, A

Wang, WR

Peltz, SW ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Mol Genet & Microbiol, Piscataway, NJ 08854 USA

[2] PTC Therapeut, S Plainfield, NJ 07080 USA

[3] Canc Inst New Jersey, Piscataway, NJ 08854 USA

来源：

GENE | 2001年 / 274卷 / 1-2期

关键词：

mRNA decay; translation; premature termination codon; downstream sequence element; heterogeneous nuclear ribonucleoprotein;

D O I：

10.1016/S0378-1119(01)00552-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Cell survival depends on the precise and correct production of polypeptides. Eukaryotic cells have evolved conserved proofreading mechanisms to get rid of incomplete and potentially deleterious proteins. The nonsense-mediated mRNA decay (NMD) pathway is an example of a surveillance mechanism that monitors premature translation termination and promotes degradation of aberrant transcripts that code for nonfunctional or even harmful proteins. In this review we will describe our current knowledge of the NMD pathway, analyzing primarily the results obtained from the yeast Saccharomyces cerevisiae, but establishing functional comparisons with those obtained in higher eukaryotes. Based on these observations, we present two related working models to explain how this surveillance pathway recognizes and selectively degrades aberrant mRNAs. (C) 2001 Published by Elsevier Science B.V.

引用

页码：15 / 25

页数：11

共 50 条

[21] Nonsense-mediated mRNA decay at the crossroads of many cellular pathways [J].

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[30] Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets [J].

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