Neutrophil dynamics in response to chemotherapy and G-CSF

被引：22

作者：

Zhuge, Changjing ^{[1
,2
]}

Lei, Jinzhi ^{[1
]}

Mackey, Michael C. ^{[2
,3
,4
,5
]}

机构：

[1] Tsinghua Univ, Zhou Pei Yuan Ctr Appl Math, Beijing 100084, Peoples R China

[2] McGill Univ, Ctr Appl Math Biosci & Med, Montreal, PQ H4X 2C1, Canada

[3] McGill Univ, Dept Physiol, Montreal, PQ H4X 2C1, Canada

[4] McGill Univ, Dept Math, Montreal, PQ H4X 2C1, Canada

[5] McGill Univ, Dept Phys, Montreal, PQ H4X 2C1, Canada

来源：

JOURNAL OF THEORETICAL BIOLOGY | 2012年 / 293卷

基金：

加拿大自然科学与工程研究理事会; 中国国家自然科学基金;

关键词：

Neutropenia; Timing; Mathematical model; Resonance; COLONY-STIMULATING FACTOR; CHRONIC MYELOGENOUS LEUKEMIA; CELL LUNG-CANCER; CYCLICAL NEUTROPENIA; HUMAN GRANULOPOIESIS; MATHEMATICAL-MODEL; DOSE-INTENSITY; KINETICS; HEMATOPOIESIS; OSCILLATIONS;

D O I：

10.1016/j.jtbi.2011.10.017

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have used a mathematical model of the combined dynamics of the hematopoietic stem cells and the differentiated neutrophil progeny to examine the effects of periodic chemotherapy in generating neutropenia, and the corresponding response of this system to granulocyte colony stimulating factor given to counteract the neutropenia. We find that there is a significant period of chemotherapy delivery that induces resonance in the system (at a period twice the average neutrophil lifespan from commitment to death) and a corresponding neutropenia suggesting that myelosuppressive protocols should avoid this period to minimize hematopoietic damage. The response to G-CSF is highly variable. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：111 / 120

页数：10

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