Tributyltin chloride induces renal dysfunction by inflammation and oxidative stress in female rats

被引：32
作者：
Coutinho, Joao V. S. [1 ]
Freitas-Lima, Leandro C. [1 ]
Freitas, Frederico F. C. T. [2 ]
Freitas, Flavia P. S. [2 ]
Podratz, Priscila L. [1 ]
Magnago, Rafaella P. L. [1 ]
Porto, Marcella L. [2 ]
Meyrelles, Silvana S. [2 ]
Vasquez, Elisardo C. [2 ]
Brandao, Poliane A. A. [3 ]
Carneiro, Maria T. W. D. [3 ]
Paiva-Melo, Francisca D. [4 ]
Miranda-Alves, Leandro [4 ,5 ]
Silva, Ian V. [1 ]
Gava, Agata L. [2 ]
Graceli, Jones B. [1 ]
机构：
[1] Univ Fed Espirito Santo, Dept Morphol, Goiabeiras, ES, Brazil
[2] Univ Fed Espirito Santo, Dept Physiol Sci, Goiabeiras, ES, Brazil
[3] Univ Fed Espirito Santo, Dept Chem, Goiabeiras, ES, Brazil
[4] Univ Fed Rio de Janeiro, Inst Biomed Sci, Expt Endocrinol Res Grp, BR-21941 Rio De Janeiro, Brazil
[5] Univ Fed Rio de Janeiro, Sch Med, Postgrad Program Endocrinol, BR-21941 Rio De Janeiro, Brazil
来源：
TOXICOLOGY LETTERS | 2016年 / 260卷
关键词：
Tributyltin chloride; Renal function; Inflammation; Oxidative stress; Estrogen; MAST-CELL INFILTRATION; I COLLAGEN-SYNTHESIS; ESTROGEN-RECEPTOR; TUBULOINTERSTITIAL FIBROSIS; EXPRESSION; EXPOSURE; ACTIVATION; TOXICITY; PATHOGENESIS; LEADS;
D O I：
10.1016/j.toxlet.2016.08.007
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Tributyltin chloride (TBT) is an organometallic pollutant that is used as a biocide in antifouling paints. TBT induces several toxic and endocrine-disrupting effects. However, studies evaluating the effects of TBT on renal function are rare. This study demonstrates that TBT exposure is responsible for improper renal function as well as the development of abnormal morphophysiology in mammalian kidneys. Female rats were treated with TBT, and their renal morphophysiology was assessed. Morphophysiological abnormalities such as decreased glomerular filtration rate and increased proteinuria levels were observed in TBT rats. In addition, increases in inflammation, collagen deposition and alpha-smooth muscle actin (alpha-SMA) protein expression were observed in TBT kidneys. A disrupted cellular redox balance and apoptosis in kidney tissue were also observed in TBT rats. TBT rats demonstrated reduced serum estrogen levels and estrogen receptor-alpha (ER alpha) protein expression in renal cortex. Together, these data provide in vivo evidence that TBT is toxic to normal renal function and that these effects may be associated with renal histopathology complications, such as inflammation and fibrosis. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：52 / 69
页数：18
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