Brain Sex in Transgender Women Is Shifted towards Gender Identity

被引：10
作者：
Kurth, Florian [1 ]
Gaser, Christian [2 ,3 ]
Sanchez, Francisco J. [4 ]
Luders, Eileen [1 ,5 ,6 ]
机构：
[1] Univ Auckland, Sch Psychol, Auckland 1010, New Zealand
[2] Jena Univ Hosp, Dept Psychiat, D-07747 Jena, Germany
[3] Jena Univ Hosp, Dept Neurol, D-07747 Jena, Germany
[4] Univ Missouri, Coll Educ & Human Dev, Columbia, MO 65211 USA
[5] Univ Southern Calif, Sch Med, Lab Neuro Imaging, Los Angeles, CA 90033 USA
[6] Uppsala Univ, Dept Womens & Childrens Hlth, S-75185 Uppsala, Sweden
来源：
JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 06期
基金：
美国国家卫生研究院;
关键词：
brain; gender identity; machine learning; MRI; sex classifier; transgender; TO-FEMALE TRANSSEXUALS; GRAY-MATTER; DIFFERENTIATION; TESTOSTERONE; BEHAVIOR; MRI; DIFFERENCE; DYSPHORIA; ESTROGEN; ANDROGEN;
D O I：
10.3390/jcm11061582
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Transgender people report discomfort with their birth sex and a strong identification with the opposite sex. The current study was designed to shed further light on the question of whether the brains of transgender people resemble their birth sex or their gender identity. For this purpose, we analyzed a sample of 24 cisgender men, 24 cisgender women, and 24 transgender women before gender-affirming hormone therapy. We employed a recently developed multivariate classifier that yields a continuous probabilistic (rather than a binary) estimate for brains to be male or female. The brains of transgender women ranged between cisgender men and cisgender women (albeit still closer to cisgender men), and the differences to both cisgender men and to cisgender women were significant (p = 0.016 and p < 0.001, respectively). These findings add support to the notion that the underlying brain anatomy in transgender people is shifted away from their biological sex towards their gender identity.
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页数：8
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