Patient and tumor characteristics of bilateral breast cancer at screening mammography in the Netherlands, a population-based study

被引:13
作者
Setz-Pels, Wikke [1 ]
Duijm, Lucien E. M. [1 ]
Groenewoud, Johanna H. [2 ]
Louwman, Marieke W. J. [3 ]
Jansen, Frits H. [1 ]
van Beek, Mike [4 ]
Plaisier, Menno L. [5 ]
Voogd, Adri C. [3 ,6 ]
机构
[1] Catharina Hosp, Dept Radiol, NL-5602 ZA Eindhoven, Netherlands
[2] Rotterdam Univ Appl Sci, Expertise Ctr Transit Care, NL-3001 HA Rotterdam, Netherlands
[3] Eindhoven Canc Registry, Comprehens Canc Ctr S IKZ, NL-5600 AE Eindhoven, Netherlands
[4] PAMM Labs, Reg Lab Pathol, NL-5602 ZA Eindhoven, Netherlands
[5] Maxima Med Ctr, Dept Radiol, NL-5500 MB Veldhoven, Netherlands
[6] Maastricht Univ, Dept Epidemiol, NL-6200 MD Maastricht, Netherlands
关键词
Bilateral breast cancer; Screening mammography; Index cancer; Contralateral cancer; Sensitivity; CONTRALATERAL BREAST; ADJUVANT THERAPY; SURVIVAL; PROGNOSIS; CARCINOMA; IMPACT; WOMEN; RISK; MORTALITY; DISEASE;
D O I
10.1007/s10549-011-1545-8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Few data are available on bilateral breast cancer in the screening population. The aim of this study was to determine patient and tumor characteristics of women with bilateral breast cancer at screening mammography. We included all 350,637 screening mammography examinations of women participating in a biennial screening program in a southern screening region of the Netherlands between May 1998 and January 2010. For referred women, all breast imaging reports, biopsy results, and surgery reports during one year after referral were collected. We compared patient and tumor characteristics of referred women with a diagnosis of bilateral breast cancer or unilateral breast cancer at workup. Bilateral or unilateral breast cancer had been diagnosed in respectively 40 (2.2%) and 1766 (97.8%) of 1806 referred women. Women with bilateral or unilateral breast cancer did not differ significantly in mean age, mammographic breast density, family history of breast cancer, or use of hormone replacement therapy. Compared with index cancers, contralateral cancers comprised significantly more lobular cancers (P = 0.02). Tumor size, mitotic activity, and estrogen receptor status were comparable for both groups, but contralateral cancers had a significantly lower risk of lymph node metastases (P = 0.03). Compared to unilateral breast cancer, contralateral malignancies in women with bilateral breast cancer comprised significantly more lobular cancers (P = 0.004) and lymph node negative cancers (P = 0.01). Contralateral breast cancers detected at screening comprise more lobular cancers and show less nodal involvement than index cancers or unilateral cancers. No differences are observed with respect to other patient and tumor characteristics.
引用
收藏
页码:955 / 961
页数:7
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