The capsaicin VR1 receptor mediates substance P release in toxin A-induced enteritis in rats

被引：58
作者：
McVey, DC
Vigna, SR
机构：
[1] Duke Univ, Med Ctr, Dept Cell Biol & Med, Durham, NC 27710 USA
[2] Vet Adm Med Ctr, Durham, NC 27710 USA
来源：
PEPTIDES | 2001年 / 22卷 / 09期
关键词：
substance P; capsazepine; vanilloid receptor subtype 1; neurogenic inflammation; intestinal inflammation; capsaicin receptor;
D O I：
10.1016/S0196-9781(01)00463-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mechanism by which Clostridium difficile toxin A causes substance P (SP) release and subsequent inflammation in the rat ileum is unknown. Pretreatment with the vanilloid receptor subtype 1 (VR1) antagonist, capsazepine. before toxin A administration significantly inhibited toxin A-induced SP release and intestinal inflammation. Intraluminal administration of the VRI agonist capsaicin caused intestinal inflammation similar to the effects of toxin A. Pretreatment with capsazepine before capsaicin administration also significantly inhibited capsaicin-induced intestinal inflammation. These results suggest that intraluminal toxin A causes SP release from primary sensory neurons via stimulation of VRI receptors resulting in intestinal inflammation. (C) 2001 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：1439 / 1446
页数：8
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