The thermal unfolding of native cytochrome c in the transition from solution to gas phase probed by native electron capture dissociation

被引：60

作者：

Breuker, K

McLafferty, FW

机构：

[1] Univ Innsbruck, Inst Organ Chem, A-6020 Innsbruck, Austria

[2] Univ Innsbruck, CMBI, A-6020 Innsbruck, Austria

[3] Cornell Univ, Baker Lab, Dept Chem & Chem Biol, Ithaca, NY 14853 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 31期

关键词：

hydration; mass spectrometry; native electron capture dissociation; noncovalent interactions; protein structures;

D O I：

10.1002/anie.200500668

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Unfolding upon dehydration:. What happens to the structure of a native protein that is suddenly exposed to vacuum? Native electron capture dissociation shows that dehydration turns the strongest intramolecular interactions in solution into the weakest in the gas phase. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4911 / 4914

页数：4

共 17 条

[11] The Role of Salt in Mitochondria: Returning Cytochrome C to its Native State After Its Dissociation from Cardiolipin Containing Membranes
Pandiscia, Leah
Schweitzer-Stenner, Reinhard
BIOPHYSICAL JOURNAL, 2014, 106 (02) : 517A - 517A
[12] Top-Down Structural Characterization of Native Ubiquitin Combining Solution-Stable Isotope Labeling, Trapped Ion Mobility Spectrometry, and Tandem Electron Capture Dissociation Mass Spectrometry
Fouque, Kevin Jeanne Dit
Fernandez-Rojas, Meiby
Roque, Anelis E.
Fernandez-Lima, Francisco
ANALYTICAL CHEMISTRY, 2024, 96 (37) : 14963 - 14970
[13] Electron capture dissociation and 13C, 15N depletion for deuterium localization in intact proteins after solution-phase exchange
Charlebois, JP
Patrie, SM
Kelleher, NL
ANALYTICAL CHEMISTRY, 2003, 75 (13) : 3263 - 3266
[14] Generating Informative Sequence Tags from Antigen-Binding Regions of Heavily Glycosylated IgA1 Antibodies by Native Top-Down Electron Capture Dissociation
Greisch, Jean-Francois
den Boer, Maurits A.
Beurskens, Frank
Schuurman, Janine
Tamara, Sem
Bondt, Albert
Heck, Albert J. R.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2021, 32 (06) : 1326 - 1335
[15] Structural Stability from Solution to the Gas Phase: Native Solution Structure of Ubiquitin Survives Analysis in a Solvent-Free Ion Mobility-Mass Spectrometry Environment
Wyttenbach, Thomas
Bowers, Michael T.
JOURNAL OF PHYSICAL CHEMISTRY B, 2011, 115 (42): : 12266 - 12275
[16] Conformations of Gas-Phase Ions of Ubiquitin, Cytochrome c, Apomyoglobin, and β-Lactoglobulin Produced from Two Different Solution Conformations
Wright, P. John
Zhang, Jianmin
Douglas, D. J.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2008, 19 (12) : 1906 - 1913
[17] The structure of the complex between the arsenite oxidase from Pseudorhizobium banfieldiae sp. strain NT-26 and its native electron acceptor cytochrome c552
Poddar, Nilakhi
Santini, Joanne M.
Maher, Megan J.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2023, 79 : 345 - 352

← 1 2 →