Memory-enhancing effect of Rhodiola rosea L extract on aged mice

被引：3
作者：
Cao, Yanjing [1 ,2 ,3 ]
Liang, Lizhen [2 ,3 ]
Xu, Jian [5 ]
Wu, Jiali [2 ,3 ]
Yan, Yongxing [2 ,3 ]
Lin, Ping [2 ,3 ]
Chen, Qiang [2 ,3 ]
Zheng, Fengming [2 ,3 ]
Wang, Qin [2 ,3 ]
Ren, Qian [2 ,3 ]
Gou, Zengmei [6 ]
Fan, Yongjun [4 ]
Du, Yifeng [1 ]
机构：
[1] Shandong Univ, Shandong Prov Hosp, Dept Neurol, Jinan 250013, Shandong, Peoples R China
[2] AnHui Med Univ, Peoples Hosp HangZhou 3, Dept Neurol, Hangzhou 310009, Zhejiang, Peoples R China
[3] AnHui Med Univ, Hosp 3, Hangzhou 310009, Zhejiang, Peoples R China
[4] Griffith Univ, Eskitis Inst Drug Discovery, Brisbane, Qld 4111, Australia
[5] ZheJiang Chinese Med Univ, Dept Histol & Embryol, Hangzhou 310053, Zhejiang, Peoples R China
[6] Second Peoples Hosp WeiFang, Dept Neurol, Weifang 261041, Shandong, Peoples R China
来源：
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH | 2016年 / 15卷 / 07期
关键词：
Rhodiola rosea; Memory function; Catalase; Acetyl cholinesterase; Open-field test; ALZHEIMERS-DISEASE; BRAIN; ACETYLCHOLINESTERASE;
D O I：
10.4314/tjpr.v15i7.14
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Purpose: The memory-enhancing effects of Rhodiola rosea L. extract (RRLE) on normal aged mice were assessed. Methods: In the open-field test, the effect of RRLE (150 and 300 mg/kg) on mouse locomotive activities was evaluated by investigating the extract's influence on CAT and AchE activities in the brain tissue of mice. Results: Compared with aged group, high dose of RRLE reduced the total distance (3212.4 +/- 123.1 cm, p < 0.05) significantly, increased catalase (CAT) activity (101.4 +/- 12.2 U/mg pro, p < 0.05), and inhibited acetyl cholinesterase (AChE) activity (0.94 +/- 0.12 U/mg pro, p < 0.05) in the brain tissue of aged mice. Conclusion: The results show that RRLE improves the memory functions of aged mice probably by increasing CAT activity while decreasing AChE activity.
引用
收藏
页码：1453 / 1457
页数：5
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