The addition of avibactam renders piperacillin an effective treatment for Mycobacterium abscessus infection in an in vivo model

被引：16

作者：

Meir, Michal ^{[1
]}

Bifani, Pablo ^{[3
,4
]}

Barkan, Daniel ^{[2
,5
]}

机构：

[1] Rambam Hlth Care Campus, Ruth Rappaport Childrens Hosp, Haifa, Israel

[2] Hebrew Univ Jerusalem, Koret Sch Vet Med, Robert H Smith Fac Agr Food & Environm, Rehovot, Israel

[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Microbiol & Immunol, Singapore, Singapore

[4] ASTAR, Singapore Immunol Network SIgN, Singapore, Singapore

[5] Sch Vet Med, Fac Agr, POB12, IL-76100 Rehovot, Israel

来源：

ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL | 2018年 / 7卷

关键词：

Mycobacterium abscessus; Combination treatment; Avibactam; Piperacillin; MIC; CYSTIC-FIBROSIS;

D O I：

10.1186/s13756-018-0448-4

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Treating M. abscessus infection is challenging due to the potent -lactamase Bla(Mab) (Beta-lactamase of M. abscessus()). Avibactam is a non--lactam, -lactamase inhibitor shown to inhibit Bla(Mab). We tested whether avibactem can render piperacillin effective against M. Abscessus. In-vitro, avibactam enhanced the activity of piperacillin by 16-32 fold, with no significant effect on meropenem. In an in-vivo Galleria mellonella model, meropenem and piperacillin/avibactam significantly decreased infection burden compared to untreated controls. Neither piperacillin nor avibactam alone had a significant effect.

引用

页数：3

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