A facile ultrasonication assisted method for Fe3O4@SiO2-Ag nanospheres with excellent antibacterial activity

被引：41

作者：

Chen, Shuang-Sheng ^{[1
]}

Xu, Hui ^{[1
]}

Xu, Hua-Jian ^{[2
]}

Yu, Guang-Jin ^{[1
]}

Gong, Xing-Long ^{[3
]}

Fang, Qun-Ling ^{[2
]}

Leung, Ken Cham-Fai ^{[4
,5
]}

Xuan, Shou-Hu ^{[3
]}

Xiong, Qi-Ru ^{[1
]}

机构：

[1] Anhui Med Univ, Affiliated Hosp 1, Dept Chirurg, Hefei 230032, Peoples R China

[2] Hefei Univ Technol, Sch Med Engn, Hefei 230009, Peoples R China

[3] Univ Sci & Technol China, Dept Modern Mech, CAS Key Lab Mech Behav & Design Mat, Hefei 230026, Peoples R China

[4] Hong Kong Baptist Univ, Dept Chem, Kowloon, Hong Kong, Peoples R China

[5] Hong Kong Baptist Univ, State Key Lab Environm & Biol Anal, Kowloon, Hong Kong, Peoples R China

来源：

DALTON TRANSACTIONS | 2015年 / 44卷 / 19期

基金：

中国国家自然科学基金;

关键词：

SILVER NANOPARTICLES; ESCHERICHIA-COLI; NANOCOMPOSITE; WATER; NANOMATERIALS; COMPOSITE; PROPERTY;

D O I：

10.1039/c5dt00977d

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

To increase the monodispersity of magnetic hybrid nanocomposites, a novel ultrasonic method was introduced to synthesize uniform Fe3O4@SiO2-Ag nanospheres. The immobilized Ag nanocrystals were tunable by varying the experimental conditions. An antibacterial assay indicated that the Fe3O4@SiO2-Ag nanospheres exhibited excellent antibacterial activities against Staphylococcus aureus and Escherichia coli, in which the minimum inhibition concentrations (MIC) were 40 mu g mL(-1) and 20 mu g mL(-1), respectively. The live/dead bacterial cell fluorescence stain assay agreed well with the antibacterial assay. The CCK-8 results indicated these nanospheres were bio-compatible for human normal cells and presented relative cytotoxicity against HepG2 tumor cells. These nanospheres could be easily uptaken by the cells and they could affect bacterial cells both inside and outside the cell membrane, which enable them to be promisingly applied in future biomedical areas.

引用

页码：9140 / 9148

页数：9