Testing and clinical implications for non-V600 BRAF mutations in metastatic NRASmt melanoma

被引：3
作者：
Richtig, G. [1 ,2 ]
Richtig, E. [2 ]
Kashofer, K. [3 ]
Koch, L. [2 ]
Winter, G. [3 ]
Hoefler, G. [3 ]
Pichler, M. [4 ]
Ehall, B. [3 ]
Grubler, M. R. [5 ,6 ]
Heinemann, A. [1 ]
Aigelsreiter, A. [3 ]
机构：
[1] Med Univ Graz, Inst Expt & Clin Pharmacol, Graz, Austria
[2] Med Univ Graz, Dept Dermatol, Graz, Austria
[3] Med Univ Graz, Inst Pathol, Graz, Austria
[4] Med Univ Graz, Div Oncol, Graz, Austria
[5] Med Univ Graz, Dept Internal Med, Div Endocrinol & Diabetol, Graz, Austria
[6] Bern Univ Hosp, Swiss Cardiovasc Ctr Bern, Dept Cardiol, Bern, Switzerland
来源：
BRITISH JOURNAL OF DERMATOLOGY | 2017年 / 177卷 / 03期
基金：
奥地利科学基金会;
关键词：
MEK; ACTIVATION;
D O I：
10.1111/bjd.15222
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
引用
收藏
页码：860 / 861
页数：2
相关论文
共 11 条
  • [1] BRAFL597 Mutations in Melanoma Are Associated with Sensitivity to MEK Inhibitors
    Dahlman, Kimberly Brown
    Xia, Junfeng
    Hutchinson, Katherine
    Ng, Charles
    Hucks, Donald
    Jia, Peilin
    Atefi, Mohammad
    Su, Zengliu
    Branch, Suzanne
    Lyle, Pamela L.
    Hicks, Donna J.
    Bozon, Viviana
    Glaspy, John A.
    Rosen, Neal
    Solit, David B.
    Netterville, James L.
    Vnencak-Jones, Cindy L.
    Sosman, Jeffrey A.
    Ribas, Antoni
    Zhao, Zhongming
    Pao, William
    [J]. CANCER DISCOVERY, 2012, 2 (09) : 791 - 797
  • [2] Dummer R, 2015, J CLIN ONCOL, V33
  • [3] Clinical Correlates of NRAS and BRAF Mutations in Primary Human Melanoma
    Ellerhorst, Julie A.
    Greene, Victoria R.
    Ekmekcioglu, Suhendan
    Warneke, Carla L.
    Johnson, Marcella M.
    Cooke, Carolyn P.
    Wang, Li-E
    Prieto, Victor G.
    Gershenwald, Jeffrey E.
    Wei, Qingyi
    Grimm, Elizabeth A.
    [J]. CLINICAL CANCER RESEARCH, 2011, 17 (02) : 229 - 235
  • [4] Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF
    Heidorn, Sonja J.
    Milagre, Carla
    Whittaker, Steven
    Nourry, Arnaud
    Niculescu-Duvas, Ion
    Dhomen, Nathalie
    Hussain, Jahan
    Reis-Filho, Jorge S.
    Springer, Caroline J.
    Pritchard, Catrin
    Marais, Richard
    [J]. CELL, 2010, 140 (02) : 209 - 221
  • [5] Loss of NF1 in Cutaneous Melanoma Is Associated with RAS Activation and MEK Dependence
    Nissan, Moriah H.
    Pratilas, Christine A.
    Jones, Alexis M.
    Ramirez, Ricardo
    Won, Helen
    Liu, Cailian
    Tiwari, Shakuntala
    Kong, Li
    Hanrahan, Aphrothiti J.
    Yao, Zhan
    Merghoub, Taha
    Ribas, Antoni
    Chapman, Paul B.
    Yaeger, Rona
    Taylor, Barry S.
    Schultz, Nikolaus
    Berger, Michael F.
    Rosen, Neal
    Solit, David B.
    [J]. CANCER RESEARCH, 2014, 74 (08) : 2340 - 2350
  • [6] Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo
    Posch, Christian
    Moslehi, Homayoun
    Feeney, Luzviminda
    Green, Gary A.
    Ebaee, Anoosheh
    Feichtenschlager, Valentin
    Chong, Kim
    Peng, Lily
    Dimon, Michelle T.
    Phillips, Thomas
    Daud, Adil I.
    McCalmont, Timothy H.
    LeBoit, Philip E.
    Ortiz-Urda, Susana
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (10) : 4015 - 4020
  • [7] Two Case Reports of Rare BRAF Mutations in Exon 11 and Exon 15 with Discussion of Potential Treatment Options
    Richtig, Georg
    Aigelsreiter, Ariane
    Kashofer, Karl
    Talakic, Emina
    Kupsa, Romana
    Schaider, Helmut
    Richtig, Erika
    [J]. CASE REPORTS IN ONCOLOGY, 2016, 9 (03): : 543 - 546
  • [8] Beyond BRAFV600: Clinical Mutation Panel Testing by Next-Generation Sequencing in Advanced Melanoma
    Siroy, Alan E.
    Boland, Genevieve M.
    Milton, Denai R.
    Roszik, Jason
    Frankian, Silva
    Malke, Jared
    Haydu, Lauren
    Prieto, Victor G.
    Tetzlaff, Michael
    Ivan, Doina
    Wang, Wei-Lien
    Torres-Cabala, Carlos
    Curry, Jonathan
    Roy-Chowdhuri, Sinchita
    Broaddus, Russell
    Rashid, Asif
    Stewart, John
    Gershenwald, Jeffrey E.
    Amaria, Rodabe N.
    Patel, Sapna P.
    Papadopoulos, Nicholas E.
    Bedikian, Agop
    Hwu, Wen-Jen
    Hwu, Patrick
    Diab, Adi
    Woodman, Scott E.
    Aldape, Kenneth D.
    Luthra, Rajyalakshmi
    Patel, Keyur P.
    Shaw, Kenna R.
    Mills, Gordon B.
    Mendelsohn, John
    Meric-Bernstam, Funda
    Kim, Kevin B.
    Routbort, Mark J.
    Lazar, Alexander J.
    Davies, Michael A.
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2015, 135 (02) : 508 - 515
  • [9] CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations
    Smalley, K. S. M.
    Xiao, M.
    Villanueva, J.
    Nguyen, T. K.
    Flaherty, K. T.
    Letrero, R.
    Van Belle, P.
    Elder, D. E.
    Wang, Y.
    Nathanson, K. L.
    Herlyn, M.
    [J]. ONCOGENE, 2009, 28 (01) : 85 - 94
  • [10] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
    Wan, PTC
    Garnett, MJ
    Roe, SM
    Lee, S
    Niculescu-Duvaz, D
    Good, VM
    Jones, CM
    Marshall, CJ
    Springer, CJ
    Barford, D
    Marais, R
    [J]. CELL, 2004, 116 (06) : 855 - 867
12