The Role of Retinal Pigment Epithelial Cells in Regulation of Macrophages/Microglial Cells in Retinal Immunobiology

被引：37
作者：
Taylor, Andrew W. [1 ]
Hsu, Samuel [1 ]
Ng, Tat Fong [1 ]
机构：
[1] Boston Univ, Sch Med, Dept Ophthalmol, Boston, MA 02118 USA
来源：
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
关键词：
ocular immune privilege; immune tolerance; retinal pigment epithelial cells (RPE); retinal immunobiology; suppressor macrophages; EXPERIMENTAL AUTOIMMUNE UVEITIS; MELANOCYTE-STIMULATING HORMONE; GROWTH-FACTOR-BETA; IMMUNOLOGICALLY PRIVILEGED SITES; IMMUNE PRIVILEGE; TIGHT-JUNCTION; MACULAR DEGENERATION; IFN-GAMMA; ALPHA-MSH; TGF-BETA;
D O I：
10.3389/fimmu.2021.724601
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The ocular tissue microenvironment is immune privileged and uses several mechanisms of immunosuppression to prevent the induction of inflammation. Besides being a blood-barrier and source of photoreceptor nutrients, the retinal pigment epithelial cells (RPE) regulate the activity of immune cells within the retina. These mechanisms involve the expression of immunomodulating molecules that make macrophages and microglial cells suppress inflammation and promote immune tolerance. The RPE have an important role in ocular immune privilege to regulate the behavior of immune cells within the retina. Reviewed is the current understanding of how RPE mediate this regulation and the changes seen under pathological conditions.
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页数：10
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